1. 28 Ultraviolet B-induced inflammatory microenvironment promotes melanocyte survival and melanoma susceptibility
- Author
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Sean Davis, Glenn Merlino, Giorgio Trinchieri, Heinz Arnheiter, E. De Fabo, Thomas J. Hornyak, Paul S. Meltzer, M. Zaidi, F P Noonan, and Elaine Fuchs
- Subjects
Cancer Research ,Melanoma ,Ultraviolet b ,Melanocyte ,Biology ,medicine.disease ,law.invention ,Pathogenesis ,medicine.anatomical_structure ,Oncology ,law ,microRNA ,medicine ,Cancer research ,Suppressor ,Gene ,Transcription factor - Abstract
During the past several years it has become clear that alterations in the expression of microRNA genes contribute to the pathogenesis of most, perhaps all, human malignancies. These alterations can be caused by a variety of mechanisms, including deletions, amplifications or mutations involving microRNA loci, by epigenetic silencing or by dysregulation of transcription factors targeting specific microRNAs. Since malignant cells show dependence on the dysregulated expression of microRNA genes, which in turn control or are controlled by dysregulation of multiple protein coding oncogenes or tumour suppressor genes, these small RNAs provide important opportunities for development of future microRNA based therapies.
- Published
- 2010
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