1. 690 Prognostic significance of estrogen receptors in 405 primary breast cancers (B.C.): A comparison of immunohistochemical (ICA) and biochemical (DCC) methods
- Author
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Rolando Nortilli, A. Tomezzoli, Rocco Micciolo, S. Modena, P. Spagnolli, Monica Turazza, Andrea Bonetti, Gianluigi Cetto, Annamaria Molino, A. Corgnati, Q. Piubello, Giovanni Paolo Pollini, E. Recaldin, E. Manfrin, Franco Bonetti, and L. Sperotto
- Subjects
Oncology ,Gynecology ,Cancer Research ,Prognostic variable ,medicine.medical_specialty ,Proportional hazards model ,business.industry ,Concordance ,Estrogen receptor ,Internal medicine ,medicine ,Immunohistochemistry ,Statistical analysis ,business - Abstract
ER were determined on 405 primary b.c. by both biochemical and immunoistochemical methods. The aim of this study was to evaluate if one of the two methods is more predictive of prognosis. We considered ERDCC + if ≥ 10 f mol/mg and ERICA+ if ≥ 45% of cells were stained. Product-limit method and Cox's proportional hazard model were used for the statistical analysis. The median follow-up was 40 months (range 4–95); 98 pts relapsed and 48 died. There is a close association between ERICA and ERDCC (concordance: 81.5%). ERICA status was significantly associated with both DFS and OS (higher in ERICA+); ERDCC status was significantly associated only with OS (higher in ERDCC+). Similar results were obtained when adjustments for the effect of other prognostic variables (pT, pN, age) were considered. A comparison of DFS and OS when ERICA and ERDCC status were jointly evaluated showed that these methods gave quite similar information on prognosis, so that it is possible to use only one technique.
- Published
- 1995