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Context: Peripheral neuropathy may affect nerve conduction in patients with diabetes mellitus., Objective: This study was designed to test the hypothesis that the electrical stimulation threshold for a motor response of the sciatic nerve is increased in patients suffering from diabetic foot gangrene compared to non-diabetic patients., Design: Prospective non-randomised trial with two parallel groups., Setting: Two university-affiliated hospitals., Participants: Patients scheduled for surgical treatment of diabetic foot gangrene (n = 30) and non-diabetic patients (n = 30) displaying no risk factors for neuropathy undergoing orthopaedic foot or ankle surgery., Main Outcome Measure: The minimum current intensity required to elicit a typical motor response (dorsiflexion or eversion of the foot) at a pulse width of 0.1 ms and a stimulation frequency of 1 Hz when the needle tip was positioned under ultrasound control directly adjacent to the peroneal component of the sciatic nerve., Results: The non-diabetic patients were younger [64 (SD 12) vs. 74 (SD 7) years] and predominantly female (23 vs. 8). The geometric mean of the motor stimulation threshold was 0.26 [95% confidence interval (95% CI) 0.24 to 0.28] mA in non-diabetic and 1.9 (95% CI 1.6 to 2.2) mA in diabetic patients. The geometric mean of the electrical stimulation threshold was significantly (P < 0.001) increased by a factor of 7.2 (95% CI 6.1 to 8.4) in diabetic compared to non-diabetic patients., Conclusion: The electrical stimulation threshold for a motor response of the sciatic nerve is increased by a factor of 7.2 in patients with diabetic foot gangrene, which might hamper nerve identification.

Context: With increasing prevalence of mitral regurgitation, even noncardiac anaesthesiologists will be confronted by this disorder and will need to be familiar with the extended haemodynamic monitoring required. The assessment of cardiac output (CO) measured by transpulmonary thermodilution (COTP) has become an accepted alternative to the CO measured by thermodilution via pulmonary artery catheter (COPAC). However, the integrity of COTP in severe mitral regurgitation requires systematic evaluation., Objective: This study was designed to test the hypothesis that transpulmonary thermodilution is compromised by severe mitral regurgitation., Design: Prospective method comparison study., Setting: Single university-affiliated hospital., Participants: Thirty patients with mitral regurgitation undergoing elective mitral valve repair., Main Outcome Measure: COTP and COPAC were determined in triplicate after induction of anaesthesia, and at the end of surgery after closure of the chest. The methods were compared using bias and precision statistics., Results: Echocardiography revealed severe mitral regurgitation in most patients (n  =  27) after induction of anaesthesia. The least significant change in COTP (the minimum change in COTP required to detect a real change with a probability of 95%) was increased under the condition of mitral regurgitation (15.4  ±  10.2% after anaesthesia induction vs. 9.3  ±  5.9% after valve repair, P = 0.008), whereas it remained constant in COPAC (9.6  ±  5.4 vs. 8.5  ±  7.2%, P = 0.55). There was no significant bias between COTP and COPAC after anaesthesia induction [mean CO, 4.03 ± 0.92 l  min; bias 0.12 l  min (95% confidence interval, CI, -0.073 to 0.311)], and after valve repair [mean CO 7.47  ±  1.44 l  min; bias 0.045 l  min (95% CI, -0.147 to 0.237)]. The percentage error was 28.4 and 13.6%, respectively., Conclusion: The results suggest that even severe mitral regurgitation has no significant impact on the accuracy of COTP. The precision of COTP was reduced under the condition of mitral regurgitation.

Background and Objective: Accurate assessment of a patient's volume status is an important goal for an anaesthetist. However, most variables assessing fluid responsiveness are either invasive or technically challenging. This study was designed to compare the accuracy of arterial pressure-based stroke volume variation (SVV) and variations in the pulse oximeter plethysmographic waveform amplitude as evaluated with the noninvasive calculated pleth variability index (PVI) with central venous pressure to predict the response of stroke volume index (SVI) to volume replacement in patients undergoing major surgery., Methods: We studied 20 patients scheduled for elective major abdominal surgery. After induction of anaesthesia, all haemodynamic variables were recorded immediately before (T1) and subsequent to volume replacement (T2) by infusion of 6% hydroxy-ethyl starch (HES) 130/0.4 (7 ml kg) at a rate of 1 ml kg min., Results: The volume-induced increase in SVI was at least 15% in 15 patients (responders) and less than 15% in five patients (nonresponders). Baseline SVV correlated significantly with changes in SVI (DeltaSVI; r = 0.80; P < 0.001) as did baseline PVI (r = 0.61; P < 0.004), whereas baseline values of central venous pressure showed no correlation to DeltaSVI. There was no significant difference between the area under the receiver operating characteristic curve for SVV (0.993) and PVI (0.973). The best threshold values to predict fluid responsiveness were more than 11% for SVV and more than 9.5% for PVI., Conclusion: Although arterial pressure-derived SVV revealed the best correlation to volume-induced changes in SVI, the results of our study suggest that both variables, SVV and PVI, can serve as valid indicators of fluid responsiveness in mechanically ventilated patients undergoing major surgery.