1. Obesity and effects of dapagliflozin on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus in the DECLARE–TIMI 58 trial
- Author
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Rafael Diaz, Stephen D. Wiviott, Marc S. Sabatine, Jindřich Špinar, Itamar Raz, Assen Goudev, Ofri Mosenzon, Deepak L. Bhatt, Avivit Cahn, Ingrid Gause-Nilsson, Kyong-Soo Park, Darren K. McGuire, Kazuma Oyama, Sabina A. Murphy, Lawrence A. Leiter, John P.H. Wilding, and Julia F Kuder
- Subjects
medicine.medical_specialty ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Overweight ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Glucosides ,Internal medicine ,medicine ,Humans ,Obesity ,Benzhydryl Compounds ,Dapagliflozin ,Sodium-Glucose Transporter 2 Inhibitors ,Heart Failure ,2. Zero hunger ,business.industry ,Hazard ratio ,Absolute risk reduction ,Atrial fibrillation ,medicine.disease ,3. Good health ,Diabetes Mellitus, Type 2 ,chemistry ,Relative risk ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Body mass index - Abstract
Aims We investigated the associations between obesity, cardiorenal events, and benefits of dapagliflozin in patients with type 2 diabetes mellitus (T2DM). Methods and results DECLARE–TIMI 58 randomized patients with T2DM and either atherosclerotic cardiovascular (CV) disease or multiple risk factors to dapagliflozin vs. placebo. Patients were stratified by body mass index (BMI, kg/m2): normal (18.5 to Conclusions In DECLARE–TIMI 58, patients with T2DM and higher BMI were more likely to have HHF and AF/AFL. Whereas relative risk reductions in CV and renal outcomes with dapagliflozin were generally consistent across the range of BMI, absolute risk reduction in obesity-related outcomes including HHF and AF/AFL tended to be larger in obese patients with T2DM. Clinical trial registration URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01730534.
- Published
- 2021