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14 results on '"Gershlick, Anthony"'

1. Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an interdisciplinary global European effort consortium†

Author

Riegger, Julia, Byrne, Robert A., Joner, Michael, Chandraratne, Sue, Gershlick, Anthony H., ten Berg, Jurrien M., Adriaenssens, Tom, Guagliumi, Giulio, Godschalk, Thea C., Neumann, Franz-Josef, Trenk, Dietmar, Feldman, Laurent J., Steg, Philippe Gabriel, Desmet, Walter, Alfonso, Fernando, Goodall, Alison H., Wojdyla, Roman, Dudek, Dariusz, Philippi, Vanessa, Opinaldo, Sheryl, Titova, Anna, Malik, Nikesh, Cotton, James, Jhagroe, Darshni A., Heestermans, Antonius A.C.M., Sinnaeve, Peter, Vermeersch, Paul, Valina, Christian, Schulz, Christian, Kastrati, Adnan, Massberg, Steffen, Adriaenssens, Tom, Buysschaert, Ian, Chausson, Mickaël, De Cock, Dries, Dens, Jo, Barbato, Emanuele, Desmet, Walter, Gautier, Sandrine, Vermeersch, Paul, Sinnaeve, Peter, Abergel, Helene, Feldman, Laurent, Jandrot-Perrus, Martine, Letourneur, Didier, Mangin, Pierre, Olivier, Véronique, Roques, Caroline, Byrne, Robert A., Chandraratne, Sue, Gratz, Matthias, Joner, Michael, Kastrati, Adnan, Kennerknecht, Elisabeth, Konrad, Ildiko, Koppara, Tobias, Massberg, Steffen, Neumann, Franz-Josef, Ntziachristos, Vasilis, Opinaldo, Sheryl, Philippi, Vanessa, Riegger, Julia, Rosenthal, Amir, Rzany, Alexander, Schulz, Christian, Steigerwald, Kristin, Tada, Tomohiso, Titova, Anna, Trenk, Dietmar, Valina, Christian, Vogelsang, Andreas, Xhepa, Erion, Bernelli, Chiara, Coccato, Micol, Guagliumi, Giulio, Komukai, Kenichi, Sirbu, Vasile, Kerch, Garry, Amoroso, Giovanni, ten Berg, Jurriën, Dewilde, Willem J.M., Godschalk, Thea C., Heestermans, Antonius A.C.M., Jhagroe, Darshni A., Wykrzykowska, Joanne J., Winkens, Mark H.M., Dudek, Dariusz, Rzeszutko, Łukasz, Wojdyla, Roman, Zasada, Wojciech, Alfonso, Fernando, Cuesta, Javier, Medina, Miguel, Berry, Colin, Cotton, James, Curzen, Nick, McEntegart, Margaret, Gerber, Robert, Gershlick, Anthony, Goodall, Alison H., Hetherington, Simon, Hill, Jonathan, Kelly, Damian, Malik, Nikesh, Oldroyd, Keith, Routledge, Helen, Shannon, Joanne, Suresh, Venkatesan, and Zahman, Azfar

Published
2016
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2. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation

Author

Ibanez, Borja, James, Stefan, Agewall, Stefan, Antunes, Manuel J., Bucciarelli-Ducci, Chiara, Bueno, Hector, Caforio, Alida L. P., Crea, Filippo, Goudevenos, John A., Halvorsen, Sigrun, Hindricks, Gerhard, Kastrati, Adnan, Lenzen, Mattie J., Prescott, Eva, Roffi, Marco, Valgimigli, Marco, Varenhorst, Christoph, Vranckx, Pascal, Widimský, Petr, Baumbach, Andreas, Bugiardini, Raffaele, Coman, Ioan Mircea, Delgado, Victoria, Fitzsimons, Donna, Gaemperli, Oliver, Gershlick, Anthony H., Gielen, Stephan, Harjola, Veli-Pekka, Katus, Hugo A., Knuuti, Juhani, Kolh, Philippe, Leclercq, Christophe, Lip, Gregory Y. H., Morais, Joao, Neskovic, Aleksandar N., Neumann, Franz-Josef, Niessner, Alexander, Piepoli, Massimo Francesco, Richter, Dimitrios J., Shlyakhto, Evgeny, Simpson, Iain A, Steg, Ph Gabriel, Terkelsen, Christian Juhl, Thygesen, Kristian, Windecker, Stephan, Zamorano, Jose Luis, Zeymer, Uwe, Ibanez, Borja, James, Stefan, Agewall, Stefan, Antunes, Manuel J., Bucciarelli-Ducci, Chiara, Bueno, Hector, Caforio, Alida L. P., Crea, Filippo, Goudevenos, John A., Halvorsen, Sigrun, Hindricks, Gerhard, Kastrati, Adnan, Lenzen, Mattie J., Prescott, Eva, Roffi, Marco, Valgimigli, Marco, Varenhorst, Christoph, Vranckx, Pascal, Widimskã½, Petr, Baumbach, Andrea, Bugiardini, Raffaele, Coman, Ioan Mircea, Delgado, Victoria, Fitzsimons, Donna, Gaemperli, Oliver, Gershlick, Anthony H., Gielen, Stephan, Harjola, Veli-Pekka, Katus, Hugo A., Knuuti, Juhani, Kolh, Philippe, Leclercq, Christophe, Lip, Gregory Y. H., Morais, Joao, Neskovic, Aleksandar N., Neumann, Franz-Josef, Niessner, Alexander, Piepoli, Massimo Francesco, Richter, Dimitrios J., Shlyakhto, Evgeny, Simpson, Iain A, Steg, Ph Gabriel, Terkelsen, Christian Juhl, Thygesen, Kristian, Windecker, Stephan, Zamorano, Jose Lui, and Zeymer, Uwe

Subjects
Quality indicator, medicine.medical_treatment, Quality indicators, Guideline, ST-segment elevation, 030204 cardiovascular system & hematology, 0302 clinical medicine, ST segment, 030212 general & internal medicine, Myocardial infarction, reproductive and urinary physiology, Emergency medical system, Evidence, Risk assessment, MINOCA, Ischaemic heart disease, Fibrinolysis, Secondary prevention, Primary percutaneous coronary intervention, Reperfusion therapy, Antithrombotics, embryonic structures, Cardiology, Acute coronary syndrome, biological phenomena, cell phenomena, and immunity, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, Acute myocardial infarction, Acute coronary syndromes, Guidelines, Antithrombotic therapy, 03 medical and health sciences, Antithrombotic, Internal medicine, medicine, Fibrinolysi, In patient, cardiovascular diseases, urogenital system, Task force, business.industry, medicine.disease, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, business
Abstract

The ESC Guidelines represent the views of the ESC and were produced after careful consideration of the scientific and medical knowledge and the evidence available at the time of their publication. The ESC is not responsible in the event of any contradiction, discrepancy and/or ambiguity between the ESC Guidelines and any other official recommendations or guidelines issued by the relevant public health authorities, in particular in relation to good use of healthcare or therapeutic strategies. Health professionals are encouraged to take the ESC Guidelines fully into account when exercising their clinical judgment, as well as in the determination and the implementation of preventive, diagnostic or therapeutic medical strategies; however, the ESC Guidelines do not override, in any way whatsoever, the individual responsibility of health professionals to make appropriate and accurate decisions in consideration of each patient's health condition and in consultation with that patient and, where appropriate and/or necessary, the patient's caregiver. Nor do the ESC Guidelines exempt health professionals from taking into full and careful consideration the relevant official updated recommendations or guidelines issued by the competent public health authorities, in order to manage each patient's case in light of the scientifically accepted data pursuant to their respective ethical and professional obligations. It is also the health professional's responsibility to verify the applicable rules and regulations relating to drugs and medical devices at the time of prescription.

Published
2017

3. Prasugrel plus bivalirudin vs. clopidogrel plus heparin in patients with ST-segment elevation myocardial infarction

Author

Schulz, Stefanie, Richardt, Gert, Laugwitz, Karl-Ludwig, Morath, Tanja, Neudecker, Julia, Hoppmann, Petra, Mehran, Roxana, Gershlick, Anthony H., Tölg, Ralph, Anette Fiedler, K., Abdel-Wahab, Mohamed, Kufner, Sebastian, Schneider, Simon, Schunkert, Heribert, Ibrahim, Tareq, Mehilli, Julinda, Kastrati, Adnan, Kastrati, A., Mehilli, J., Richardt, G., Mehran, R., Gershlick, A., Mehilli, J., Burgdorf, C., Byrne, R.A., Cassese, S., Fusaro, M., Hausleiter, J., Hengstenberg, C., Joner, M., Kasel, M., Kastrati, A., Massberg, S., Ott, I., Pache, J., Schunkert, H., Seyfarth, M., Sibbing, D., Tiroch, K., Laugwitz, K.-L., Ibrahim, T., Hoppmann, P., Schneider, S., Bradaric, C., Richardt, G., Abdel-Wahab, M., Geist, V., Schwarz, B., Sulimov, D., Tölg, R., Schulz, S., Schömig, G., von Merzljak, B., Luckmann, J., Ruf, J., Morath, T., Holle, H., Paul, H., Vogel, J., Hoesl, K., Rifatov, N., Pastor, I., Maimer-Rodrigues, F., Schulz, M., Neudecker, J., Mayer, K., Hofmann, F., Mann, J., Hauschke, D., Schmitt, C., Poci, D., Barthel, P., Ndrepepa, G., Keta, D., Byrne, R.A., Kufner, S., Piniek, S., Hurt, S., Kastrati, S., and Anette Fiedler, K.

Published
2014
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5. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC)

Author

Steg, Ph. Gabriel, James, Stefan K., Atar, Dan, Badano, Luigi P., Lundqvist, Carina Blomstrom, Borger, Michael A., Di Mario, Carlo, Dickstein, Kenneth, Ducrocq, Gregory, Fernandez-Aviles, Francisco, Gershlick, Anthony H., Giannuzzi, Pantaleo, Halvorsen, Sigrun, Huber, Kurt, Juni, Peter, Kastrati, Adnan, Knuuti, Juhani, Lenzen, Mattie J., Mahaffey, Kenneth W., Valgimigli, Marco, vanʼt Hof, Arnoud, Widimsky, Petr, Zahger, Doron, Bax, Jeroen J., Baumgartner, Helmut, Ceconi, Claudio, Dean, Veronica, Deaton, Christi, Fagard, Robert, Funck-Brentano, Christian, Hasdai, David, Hoes, Arno, Kirchhof, Paulus, Knuuti, Juhani, Kolh, Philippe, McDonagh, Theresa, Moulin, Cyril, Popescu, Bogdan A., Reiner, Željko, Sechtem, Udo, Sirnes, Per Anton, Tendera, Michal, Torbicki, Adam, Vahanian, Alec, Windecker, Stephan, Hasdai, David, Astin, Felicity, Åström-Olsson, Karin, Budaj, Andrzej, Clemmensen, Peter, Collet, Jean-Philippe, Fox, Keith A., Fuat, Ahmet, Gustiene, Olivija, Hamm, Christian W., Kala, Petr, Lancellotti, Patrizio, Maggioni, Aldo Pietro, Merkely, Béla, Neumann, Franz-Josef, Piepoli, Massimo F., Van de Werf, Frans, Verheugt, Freek, and Wallentin, Lars

Published
2012
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6. Chronic infarct size after spontaneous coronary artery dissection: implications for pathophysiology and clinical management

Author

Al-Hussaini, Abtehale, primary, Abdelaty, Ahmed M S E K, additional, Gulsin, Gaurav S, additional, Arnold, Jayanth R, additional, Garcia-Guimaraes, Marcos, additional, Premawardhana, Diluka, additional, Budgeon, Charley, additional, Wood, Alice, additional, Natarajan, Nalin, additional, Mangion, Kenneth, additional, Rakhit, Roby, additional, Hoole, Stephen P, additional, Johnson, Thomas W, additional, Berry, Colin, additional, Hudson, Ian, additional, Gershlick, Anthony H, additional, Ladwiniec, Andrew, additional, Kovac, Jan, additional, Squire, Iain, additional, Samani, Nilesh J, additional, Plein, Sven, additional, McCann, Gerry P, additional, and Adlam, David, additional

Published
2020
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10. Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an interdisciplinary global European effort consortium

Author

Riegger, Julia, Byrne, Robert A., Joner, Michael, Chandraratne, Sue, Gershlick, Anthony H., ten Berg, Jurrien M., Adriaenssens, Tom, Guagliumi, Giulio, Godschalk, Thea C., Neumann, Franz-Josef, Trenk, Dietmar, Feldman, Laurent J., Steg, Philippe Gabriel, Desmet, Walter, Alfonso, Fernando, Goodall, Alison H., Wojdyla, Roman, Dudek, Dariusz, Philippi, Vanessa, Opinaldo, Sheryl, Titova, Anna, Malik, Nikesh, Cotton, James, Jhagroe, Darshni A., Heestermans, Antonius A.C.M., Sinnaeve, Peter, Vermeersch, Paul, Valina, Christian, Schulz, Christian, Kastrati, Adnan, Massberg, Steffen, Buysschaert, Ian, Chausson, Mickaël, De Cock, Dries, Dens, Jo, Barbato, Emanuele, Gautier, Sandrine, Abergel, Helene, Feldman, Laurent, Jandrot-Perrus, Martine, Letourneur, Didier, Mangin, Pierre, Olivier, Véronique, Roques, Caroline, Gratz, Matthias, Kennerknecht, Elisabeth, Konrad, Ildiko, Koppara, Tobias, Ntziachristos, Vasilis, Rosenthal, Amir, Rzany, Alexander, Steigerwald, Kristin, Tada, Tomohiso, Vogelsang, Andreas, Xhepa, Erion, Bernelli, Chiara, Coccato, Micol, Komukai, Kenichi, Sirbu, Vasile, Kerch, Garry, Amoroso, Giovanni, ten Berg, Jurriën, Dewilde, Willem J.M., Wykrzykowska, Joanne J., Winkens, Mark H.M., Rzeszutko, Łukasz, Zasada, Wojciech, Cuesta, Javier, Medina, Miguel, Berry, Colin, Curzen, Nick, McEntegart, Margaret, Gerber, Robert, Gershlick, Anthony, Hetherington, Simon, Hill, Jonathan, Kelly, Damian, Oldroyd, Keith, Routledge, Helen, Shannon, Joanne, Suresh, Venkatesan, Zahman, Azfar, Riegger, Julia, Byrne, Robert A, Joner, Michael, Chandraratne, Sue, Gershlick, Anthony H, Ten Berg, Jurrien M, Adriaenssens, Tom, Guagliumi, Giulio, Godschalk, Thea C, Neumann, Franz Josef, Trenk, Dietmar, Feldman, Laurent J, Steg, Philippe Gabriel, Desmet, Walter, Barbato, Emanuele, Alfonso, Fernando, Goodall, Alison H, Wojdyla, Roman, Dudek, Dariusz, Philippi, Vanessa, Opinaldo, Sheryl, Titova, Anna, Malik, Nikesh, Cotton, Jame, Jhagroe, Darshni A, Heestermans, Antonius A. C. M, Sinnaeve, Peter, Vermeersch, Paul, Valina, Christian, Schulz, Christian, Kastrati, Adnan, Massberg, Steffen, Department of Embryology and Genetics, Cardio-vascular diseases, Clinical sciences, and Follicle Biology

Subjects
Male, 0301 basic medicine, Cardiac & Cardiovascular Systems, Stent thrombosi, Stent thrombosis, Neutrophils, medicine.medical_treatment, Eosinophil, 030204 cardiovascular system & hematology, Fibrinogen, Neutrophil extracellular traps, ESC FASTTRACK, VIVO, Leukocyte Count, 0302 clinical medicine, Coronary thrombosis, Prospective Studies, Myocardial infarction, HYPERSENSITIVITY, Thrombectomy, RISK, biology, Neutrophil, Platelet, Graft Occlusion, Vascular, Drug-Eluting Stents, ddc, Prosthesis Failure, 3. Good health, cardiovascular system, ESC Basic and Translational Science Hot Line, Fast Track, Female, Stents, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, circulatory and respiratory physiology, medicine.drug, Platelets, Blood Platelets, medicine.medical_specialty, Thrombus aspiration, COAGULATION, Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Investigators, Histopathology, 1102 Cardiovascular Medicine And Haematology, Fibrin, 03 medical and health sciences, Percutaneous Coronary Intervention, medicine, Humans, cardiovascular diseases, Thrombus, Aged, Science & Technology, business.industry, ACUTE CORONARY SYNDROMES, Coronary Thrombosis, Stent, Percutaneous coronary intervention, Thrombosis, medicine.disease, Lymphocyte Subsets, Surgery, Eosinophils, 030104 developmental biology, Cardiovascular System & Hematology, Cardiovascular System & Cardiology, INNATE IMMUNITY, biology.protein, IMPLANTATION, business, Complication, Neutrophil extracellular trap, GENERATION
Abstract

BACKGROUND: Stent thrombosis (ST) is a rare but serious complication following percutaneous coronary intervention. Analysis of thrombus composition from patients undergoing catheter thrombectomy may provide important insights into the pathological processes leading to thrombus formation. We performed a large-scale multicentre study to evaluate thrombus specimens in patients with ST across Europe. METHODS: Patients presenting with ST and undergoing thrombus aspiration were eligible for inclusion. Thrombus collection was performed according to a standardized protocol and specimens were analysed histologically at a core laboratory. Serial tissue cross sections were stained with haematoxylin-eosin (H&E), Carstairs and Luna. Immunohistochemistry was performed to identify leukocyte subsets, prothrombotic neutrophil extracellular traps (NETs), erythrocytes, platelets, and fibrinogen. RESULTS: Overall 253 thrombus specimens were analysed; 79 (31.2%) from patients presenting with early ST, 174 (68.8%) from late ST; 79 (31.2%) were from bare metal stents, 166 (65.6%) from drug-eluting stents, 8 (3.2%) were from stents of unknown type. Thrombus specimens displayed heterogeneous morphology with platelet-rich thrombus and fibrin/fibrinogen fragments most abundant; mean platelet coverage was 57% of thrombus area. Leukocyte infiltrations were hallmarks of both early and late ST (early: 2260 ± 1550 per mm(2) vs. late: 2485 ± 1778 per mm(2); P = 0.44); neutrophils represented the most prominent subset (early: 1364 ± 923 per mm(2) vs. late: 1428 ± 1023 per mm(2); P = 0.81). Leukocyte counts were significantly higher compared with a control group of patients with thrombus aspiration in spontaneous myocardial infarction. Neutrophil extracellular traps were observed in 23% of samples. Eosinophils were present in all stent types, with higher numbers in patients with late ST in sirolimus-and everolimus-eluting stents. CONCLUSION: In a large-scale study of histological thrombus analysis from patients presenting with ST, thrombus specimens displayed heterogeneous morphology. Recruitment of leukocytes, particularly neutrophils, appears to be a hallmark of ST. The presence of NETs supports their pathophysiological relevance. Eosinophil recruitment suggests an allergic component to the process of ST. ispartof: European Heart Journal vol:37 issue:19 pages:1538-1549 ispartof: location:England status: published

Published
2015

11. Strategies to attenuate micro-vascular obstruction during P-PCI: the randomized reperfusion facilitated by local adjunctive therapy in ST-elevation myocardial infarction trial

Author

Nazir, Sheraz A., primary, McCann, Gerry P., additional, Greenwood, John P., additional, Kunadian, Vijay, additional, Khan, Jamal N., additional, Mahmoud, Islam Z., additional, Blackman, Daniel J., additional, Been, Martin, additional, Abrams, Keith R., additional, Shipley, Lorraine, additional, Wilcox, Robert, additional, Adgey, A.A. Jennifer, additional, and Gershlick, Anthony H., additional

Published
2016
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12. High-risk NSTE-ACS: high time for robust data.

Author

Kite, Thomas A and Gershlick, Anthony H

Subjects
GUIDELINES, ACUTE coronary syndrome
Abstract

The article presents the discussion on 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation.

Published
2021
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14. A randomized multicentre trial to compare revascularization with optimal medical therapy for the treatment of chronic total coronary occlusions.

Author

Werner GS, Martin-Yuste V, Hildick-Smith D, Boudou N, Sianos G, Gelev V, Rumoroso JR, Erglis A, Christiansen EH, Escaned J, di Mario C, Hovasse T, Teruel L, Bufe A, Lauer B, Bogaerts K, Goicolea J, Spratt JC, Gershlick AH, Galassi AR, and Louvard Y

Subjects
Aged, Angina Pectoris etiology, Chronic Disease, Coronary Occlusion complications, Female, Humans, Male, Middle Aged, Quality of Life, Adrenergic beta-Antagonists therapeutic use, Angina Pectoris therapy, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Coronary Occlusion therapy, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Nitrates therapeutic use, Percutaneous Coronary Intervention, Platelet Aggregation Inhibitors therapeutic use
Abstract

Aims: The clinical value of percutaneous coronary intervention (PCI) for chronic coronary total occlusions (CTOs) is not established by randomized trials. This study should compare the benefit of PCI vs. optimal medical therapy (OMT) on the health status in patients with at least one CTO., Method and Results: Three hundred and ninety-six patients were enrolled in a prospective randomized, multicentre, open-label, and controlled clinical trial to compare the treatment by PCI with OMT with a 2:1 randomization ratio. The primary endpoint was the change in health status assessed by the Seattle angina questionnaire (SAQ) between baseline and 12 months follow-up. Fifty-two percent of patients have multi-vessel disease in whom all significant non-occlusive lesions were treated before randomization. An intention-to-treat analysis was performed including 13.4% failed procedures in the PCI group and 7.3% cross-overs in the OMT group. At 12 months, a greater improvement of SAQ subscales was observed with PCI as compared with OMT for angina frequency [5.23, 95% confidence interval (CI) 1.75; 8.71; P = 0.003], and quality of life (6.62, 95% CI 1.78-11.46; P = 0.007), reaching the prespecified significance level of 0.01 for the primary endpoint. Physical limitation (P = 0.02) was also improved in the PCI group. Complete freedom from angina was more frequent with PCI 71.6% than OMT 57.8% (P = 0.008). There was no periprocedural death or myocardial infarction. At 12 months, major adverse cardiac events were comparable between the two groups., Conclusion: Percutaneous coronary intervention leads to a significant improvement of the health status in patients with stable angina and a CTO as compared with OMT alone., Trial Registration: NCT01760083.

Published
2018
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