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Introduction In the present study, we investigate the association of acute-to-chronic (A/C) glycemic ratio with no-reflow (NR) development in ST elevation myocardial infarction (STEMI) patients following primary percutaneous coronary intervention (PCI). Material and methods This retrospective study included 905 consecutive STEMI patients who were treated with primary PCI. The A/C glycemic ratio was determined as admission blood glucose (ABG) divided by the estimated average glucose (eAG). We evaluated two primary models (full model and reduced model).The primary outcome was the presence of NR. Results The incidence of NR was 22.7% (206 cases) in the present study. We divided the study population into three tertiles (T1, T2, and T3) based on the ABG/eAG ratio. There was a stepwise increase of the frequency of NR development from the T1 to T3 group (36 patients [12%] vs. 70 patients [23%] vs. 100 patients [33%]; respectively [p Conclusion To the best of our knowledge, this might be the first study showing a significant relationship between the ABG/eAG ratios with NR in STEMI patients after primary PCI. Figure 1 Funding Acknowledgement Type of funding source: None

The National Institutes of Health (NIH) and Pulmonary Hypertension Connection (PHC) registry formulas are two different equations which are based on same hemodynamic measures,mean pulmonary arterial pressure (PAPm), mean right atrial pressure (RAPm) and cardiac index (CI),and have been used to predict survival in pts with pulmonary arterial hypertension (PAH). Although the difference between survival estimates (SE) predicted by PHC and NIH was reported, the clinical relevance of either NIH or PHC equations for SE in pts with PAH remains to be determined. We aimed to assess observed survival (OS) and compare with the baseline SE's according to NIH and PHC models in pts with pulmonary hypertension (PH) included in the EUPHRATES (EvalUation of Pulmonary Hypertension Risk factors AssociaTEd with Survival) single-center registry.The study population comprised 184 pts (F 110,M74,age 49±16 yrs) with PH in whom diagnosis confirmed by cardiac catheterization. Pulmonary arterial systolic and mean pressures,and RAPm were 96.3±28 and 60.2±14 mm Hg,and 12.2±6 mm Hg,respectively. Vasoreactivity was negative in all pts. Cardiac index, pulmonary and systemic vascular resistance (PVR,SVR) and PVR/SVR ratio were 2.59±0.82 lt/min m2, 10.6±3.5 WU and 21.6+2.4 WU, and 0.49±0,2, respectively.Etiologic sungroups were as follows; Idiopathic PAH in 44 pts, PAH associated with congenital heart defects (CHD-APAH) in 70 pts, other subgroups of PAH in 9 pts,group 3 PH in 17 pts, and group 4 PH in 44 pts.Targeted treatment modalities were as follows; Bosentan (Bos) in 54%,sildenafil (Sil) in 6%, Bos+Sil in 4%, Bos+inh iloprost (iILO) in 5%, Sil+iILO 4%, Bos+Sil+iILO 8%, Bos+Sil+sc Treprostinil 1%, PTEA with iILO,Sil or Bos in 18% of the pts. Mean FU was 25±20 (2 to 82) months. Observed survival and SE's according to NIH and PHC equations were as follows: 1-year OS and SE % were 90, 68 and 92; 2-year OS and SE% were 83, 55 and 84.6; 3-year OS and SE% were 83,48 and 78, and 5-year OS and SE% were 60,30 and 65.8, respectively. The five-year curves of OS and SE's predicted by PHC model showed comparable results (p=NS) whereas NIH equation revealed significantly lower h 1-, 2-,3- and 5-year SE's than OS and SE's predicted by PHC (p

Two-dimensional (2D), tissue Doppler (TD) and 2D speckle tracking (ST) echocardiography (E) have been used in the functional assessment of right and left atrium and ventricle (RA, LA, RV and LV) in pts with pulmonary hypertension (PH). We aimed to assess the relationship among parameters of 2DE,TDE and STE,and to compare these measures in predicting the three-year mortality (3YM) in pts with PH.Our study group comprised 184 pts (F110,M74,age 49±16 yrs) in whom PH confirmed by cardiac catheterization (Cath) and treated with targeted PH agents. Pulmonary arterial systolic and mean pressures were 96.3±28 and 60.2±14 mm Hg, and PVR and PVR/SVR ratio were 10,6±3,5 WU and 0,49±0,2, respectively. Echocardiography was performed before Cath,and included assessment of pericardial effusion (PE), leftward interatrial septal bulging (IASb), RV, LV, RA and LA area (A), RA/LA and RV/LV area ratio (AR), systolic and diastolic eccentricty indexes (EIs, EId), tricuspid annular systolic excursion and velocity (TAPSE and St), and global and segmentary strain (GS,SS). Analysis of RV and LV longitudinal strain (LS), and LV radial and circumferential strain (RS and CS) were performed using the 6-segment model for RV and LV. Right ventricle GLS showed a mild correlation with LVEIs (r: -0.26,p 2.7 (AUC: 0.69; 0.57-0.80, p=0.004), RV/LV AR >1.26 (AUC: 0.76; 0.64-0.85, p=0.002), LVA