1. The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials
- Author
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Preiss, David, Campbell, Ross T, Murray, Heather M, Ford, Ian, Packard, Chris J, Sattar, Naveed, Rahimi, Kazem, Colhoun, Helen M, Waters, David D, LaRosa, John C, Amarenco, Pierre, Pedersen, Terje R, Tikkanen, Matti J, Koren, Michael J, Poulter, Neil R, Sever, Peter S, Ridker, Paul M, MacFadyen, Jean G, Solomon, Scott D, Davis, Barry R, Simpson, Lara M, Nakamura, Haruo, Mizuno, Kyoichi, Marfisi, Rosa M, Marchioli, Roberto, Tognoni, Gianni, Athyros, Vasilios G, Ray, Kausik K, Gotto, Antonio M, Clearfield, Michael B, Downs, John R, and McMurray, John J
- Subjects
Clinical Trials and Supportive Activities ,Cardiovascular ,Clinical Research ,Prevention ,Heart Disease ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Female ,Heart Failure ,Humans ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Male ,Middle Aged ,Myocardial Infarction ,Randomized Controlled Trials as Topic ,Risk Factors ,Secondary Prevention ,Treatment Outcome ,Statin ,Heart failure ,Randomized trial ,Meta-analysis ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Cardiovascular System & Hematology - Abstract
AimsThe effect of statins on risk of heart failure (HF) hospitalization and HF death remains uncertain. We aimed to establish whether statins reduce major HF events.Methods and resultsWe searched Medline, EMBASE, and the Cochrane Central Register of Controlled Trials for randomized controlled endpoint statin trials from 1994 to 2014. Collaborating trialists provided unpublished data from adverse event reports. We included primary- and secondary-prevention statin trials with >1000 participants followed for >1 year. Outcomes consisted of first non-fatal HF hospitalization, HF death and a composite of first non-fatal HF hospitalization or HF death. HF events occurring
- Published
- 2015