1. Quinidine plus verapamil vs. quinidine alone to prevent recurrences of atrial fibrillation
- Author
-
Angelo Amato Vicenzo de Paola and Henrique H. Veloso
- Subjects
Quinidine ,medicine.medical_specialty ,business.industry ,Sotalol ,Atrial fibrillation ,Torsades de pointes ,medicine.disease ,Anesthesia ,Internal medicine ,cardiovascular system ,Cardiology ,Medicine ,Verapamil ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
The excellent PAFAC1 and SOPAT2 trials demonstrated that quinidine, in combination with verapamil, is at least equivalent to sotalol in the prevention of recurrences of atrial fibrillation (AF). The combination of verapamil with quinidine in this setting may be beneficial for several reasons. First, verapamil has the ability of suppressing after depolarizations underlying the onset of torsades de pointes, which justifies the low rate of pro-arrhythmic events observed with quinidine during the follow-up period of these trials.1–3 Secondly, it has been already demonstrated that …
- Published
- 2005