1. Added-value of molecular imaging in myocardial metastasis of an ileal neuroendocrine tumour treated with peptide receptor radionuclide therapy: a case report
- Author
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Estephany Abou Jokh Casas, Virginia Pubul Núñez, María Del Carmen Mallón Araujo, and Charigan Abou Jokh Casas
- Subjects
medicine.medical_specialty ,Case Report ,030204 cardiovascular system & hematology ,Neuroendocrine tumors ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Carcinoid valvulopathy ,medicine ,Neoplasm ,AcademicSubjects/MED00200 ,030212 general & internal medicine ,Cardiac metastasis ,Gastrointestinal tract ,Tricuspid valve ,business.industry ,68Ga-DotatatePET/TC ,medicine.disease ,NET ,medicine.anatomical_structure ,Ventricle ,Radionuclide therapy ,cardiovascular system ,Radiology ,PRRT ,Transthoracic echocardiogram ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Neuroendocrine tumours (NET) conform a rare type of neoplasm, mostly located in the gastrointestinal tract. They are slow-growing tumours, so at the time of the diagnosis, most patients present with metastatic lesions, mainly in the liver. The myocardium is a rare and important organ for metastasis, in which 68Ga-Dotatate positron emission tomography-computed tomography (PET/CT) shows a high diagnostic sensitivity for its detection, contrary to carcinoid valve disease, where anatomic imaging plays a key role, especially the echocardiogram. Case summary A 60-year-old man diagnosed with metastatic progressive ileal NET, who underwent a 68Ga-Dotatate PET/CT prior 177Lu-Dotatate therapy, showed a metastatic lesion in the left ventricle that was undetected in previous studies, such as an Octreoscan® and CT. A transthoracic echocardiogram was performed revealing the existence of a second cardiac lesion, a tricuspid valve carcinoid disease. A cardiac magnetic resonance showed no late gadolinium enhancement. Discussion The 68Ga-Dotatate PET/CT is currently considered the gold standard for assessment and follow-up of NET, including those with rare sites of metastasis such as cardiac infiltration. In this case, it stimulated the persue of possible cardiac involvement, detecting the coexistence of two types of lesions (cardiac metastasis and carcinoid valve disease). Of these, carcinoid valvulopathy develops in 50% of NET cases, while cardiac metastasis (CM) is less frequent (only 5%).
- Published
- 2021