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Purpose: This study aimed to investigate the presence of choroidal vascular parameters, which have a predictive value for diabetic macular edema (DME) development, in eyes with non-proliferative diabetic retinopathy (NPDR). Methods: 148 eyes of 120 patients were included in the study. Eyes with an untreated mild-to-moderate NPDR stage were divided into 2 groups as those with and without DME. The diabetic retinopathy (DR) group was created from the eyes of patients diagnosed with diabetes mellitus without DR. Choroidal layers were segmented using the enhanced depth imag- ing mode of spectral domain optical coherence tomography. Choroidal vascular indexes (CVI) of the full-thickness choroid, sattler-choriocapillaris layer, and Haller's layer were calculated separately. Results: Full-thickness CVI values of the choroid were 65.2±3.1% in the DR-group, 64.2±3.4% in the DME-group, and 64.8±3.08% in the DME+ group (P = 0.318). The CVI values in the Sattler-choriocapillaris complex were 71.3±4.5% in the DR- group, 70.9±5.9% in the DME-group, and 71.7±5.2% in the DME+ group (P = 0.746). The CVI values in the Haller layer were 61.6±4.1% in the DR-group, 60.3±3.7% in the DME-group, and 61.1±3.1% in the DME+ group (P = 0.252). Conclusion: There was no significant difference between NPDR eyes with and without DME and eyes without DR in terms of CVI. These results may suggest that DME develops due to retinal vascular factors rather than choroidal vascular factors. [ABSTRACT FROM AUTHOR]

Purpose: The objective is to determine the effect of ectopic inner foveal layer (EIFL) thickness on preoperative and postoperative best-corrected visual acuity (BCVA) and metamorphopsia scores in stage 3 epiretinal membranes (ERM). Methods: Thirty eyes of 28 patients were included in the study. All patients underwent uncomplicated vitrectomy and membrane peeling. EIFL, central foveal thickness (CFT), outer nuclear layer (ONL), inner nuclear layer (INL), inner plexiform layer (IPL) thicknesses were measured preoperatively and postoperatively at 3 months using Spectralis spectral-domain optical cohorence tomography. Horizontal line (MH) and vertical line (MV) metamorphopsia scores were calculated using M-CHARTS. Postoperative changes in OCT parameters and visual functions and the correlations between them were analyzed. Results: EIFL thickness, ONL thickness, and CFT were 143.1±19.1 µm, 189.3±48 µm, and 431.7±58 µm preoperatively, respectively. In the postoperative 3rd month, they were 131.2±17.3 µm, 163.5±45.1 µm, and 388.2±52.6 µm (P=0.004, P=0.001, P=0.001 respectively). BCVA (logMAR: Logarithm of the minimal angle of resolution), MH, and MV scores at the postoperative 3rd month were significantly lower than their preoperative values (P<0.001 in all three). Preoperative CFT was found to be correlated with preoperative MH and MV (P=0.031, P=0.02, respectively). Preoperative ONL thickness was correlated with MH and MV scores (P=0.049, P=0.014, respectively). Preoperative INL thickness was only positively correlated with the MH score (P=0.004). There was no correlation between preoperative - postoperative OCT parameters and postoperative visual functions. Conclusion: EIFL thickness had no effect on metamorphopsia and BCVA in stage 3 ERM patients. It was thought that the formation of metamorphopsia in these patients might be due to changes in the outer retinal layers. [ABSTRACT FROM AUTHOR]