1. Associations between interleukin-10 polymorphisms and susceptibility to juvenile idiopathic arthritis: a systematic review and meta-analysis
- Author
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Nima Rezaei, Amene Saghazadeh, Saharnaz Nedjat, and Sara Harsini
- Subjects
medicine.medical_specialty ,Clinical Biochemistry ,Immunology ,Protective factor ,Arthritis ,Polymorphism, Single Nucleotide ,Gastroenterology ,Pathogenesis ,Genetic Heterogeneity ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Genotype ,medicine ,Humans ,Immunology and Allergy ,Genetic Predisposition to Disease ,030212 general & internal medicine ,Allele ,Genetic Association Studies ,030203 arthritis & rheumatology ,business.industry ,Haplotype ,medicine.disease ,Arthritis, Juvenile ,Interleukin-10 ,Interleukin 10 ,Haplotypes ,Meta-analysis ,business ,Publication Bias - Abstract
Cytokine genes, including interleukin-10 (IL-10), are known to play important roles in the pathogenesis of juvenile idiopathic arthritis (JIA). This study aims to determine whether the IL-10 polymorphisms confer susceptibility to JIA.A meta-analysis was performed on the associations between the IL-10 -1082 G/A, -592 C/A, and -819 C/T polymorphisms and JIA. A total number of 7 studies involving 1,785 patients and 6,142 controls were considered in the meta-analysis.Meta-analysis of the IL-10 -592 C/A and -819 C/T polymorphisms showed no association with JIA in the study participants, or in Caucasian or Middle Eastern participants. Meta-analysis of the IL-10 -1082 A allele in all study participants, Caucasian and Middle Eastern, showed significant associations with RA (overall ORs were 1.17, 1.15, and 1.41, respectively). Meta-analysis of the AA versus GG genotype of the IL-10 -1082 G/A polymorphism revealed significant associations with JIA (OR = 3.66, 95% CI = 1.44-9.29, P = 0.006) in participants from Middle Eastern countries. Additionally, meta-analysis of the GG versus AA+GA genotypes of the IL-10 -1082 G/A polymorphism revealed the GG genotype as the protective factor against JIA in the Middle Eastern subgroup (OR = 0.44, 95% CI = 0.20-0.94, P = 0,04). Moreover, meta-analysis of the IL-10 -1082 A allele in 4 studies on Hardy-Weinberg equilibrium showed a significant association with JIA (OR = 1.17, 95% CI = 1.07-1.28, P = 0.0009). No association was found between the IL-10 (-1082, -819, -592) ACC, ATA, and GCC haplotypes and JIA.These results suggest that the IL-10 -1082 G/A polymorphism confers susceptibility to JIA.
- Published
- 2018