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Start Over Descriptor "Metreleptin" Journal european child & adolescent psychiatry
3 results on '"Metreleptin"'

1. Case report: clinical improvements observed in first off-label metreleptin treatment of a patient with atypical anorexia nervosa.

Author

Hebebrand, Johannes, Antel, Jochen, and Peters, Triinu

Subjects
*OFF-label use (Drugs), *WEIGHT loss, *PHOBIAS, *LEPTIN, *BODY mass index, *MAGNESIUM, *VISUAL analog scale, *HUNGER, *APPETITE, *SERUM, *HEART beat, *ANOREXIA nervosa, *DRUG efficacy, *DIASTOLIC blood pressure, *AFFECT (Psychology), *SLEEP quality, *INTERPERSONAL relations, *SYSTOLIC blood pressure, *MENTAL depression, *AMENORRHEA, *MUTISM, *NAUSEA, *WEIGHT gain, *THERAPEUTICS
Abstract

Off-label metreleptin treatment resulted in cognitive, emotional and behavioral improvements of patients with anorexia nervosa, who presented with hypoleptinemia. We now report a case study of a 16-year-old female patient with atypical anorexia nervosa who was treated off-label with metreleptin for 11 days. She had lost 21 kg over 6 months. Her body mass index at referral for inpatient treatment was 20 kg/m2, her serum leptin level was just within the normal range (2.4 ng/ml). Dosing resulted in prominent improvements of mood and weight phobia entailing a comparatively brief inpatient treatment. The observed improvements are similar to those observed in patients with AN, suggesting overlapping mechanisms with respect to clinical effects induced by elevations of absolute or relative hypoleptinemia. Randomized controlled trials are warranted for both eating disorders. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Rapid amelioration of anorexia nervosa in a male adolescent during metreleptin treatment including recovery from hypogonadotropic hypogonadism.

Author

Antel, Jochen, Tan, Susanne, Grabler, Marvin, Ludwig, Christine, Lohkemper, Dominik, Brandenburg, Tim, Barth, Nikolaus, Hinney, Anke, Libuda, Lars, Remy, Miriam, Milos, Gabriella, and Hebebrand, Johannes

Subjects
*HYPOGONADISM, *LEPTIN, *CONVALESCENCE, *TESTOSTERONE, *LIBIDO, *STARVATION, *ACCELEROMETRY, *ANOREXIA nervosa, *OFF-label use (Drugs)
Abstract

With this case report we support our medical hypothesis that metreleptin treatment ameliorates starvation related emotional, cognitive and behavioral symptomatology of anorexia nervosa (AN) and show for the first time strong effects in a male patient with AN. A 15.9 year old adolescent with severe AN of eight-month duration was treated off-label with metreleptin. Hyperactivity was assessed with accelerometry. Visual analogue scales (VAS), validated self- and clinician rating scales and lab results tracked changes from baseline to end of the 24-day dosing period and a five-month follow-up. Substantial improvements of mood and eating disorder related cognitions and hyperactivity set in after two days of treatment. During dosing, sub-physiological testosterone and TT3 levels normalized; clinically libido reemerged. Weight did not increase substantially during the dosing period. During follow-up target weight was attained; mood did not deteriorate; hyperactivity ceased. The results substantiate the strong effects seen in female cases and underscore the need for a double-blind placebo-controlled trial to confirm the observed strong, multiple and rapid onset beneficial effects of metreleptin in AN. [ABSTRACT FROM AUTHOR]

Published
2022
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3. Rapid amelioration of anorexia nervosa in a male adolescent during metreleptin treatment including recovery from hypogonadotropic hypogonadism

Author

Susanne Tan, Lars Libuda, Gabriella Milos, Miriam Remy, Tim Brandenburg, Anke Hinney, Dominik Lohkemper, N. Barth, Christine Ludwig, Johannes Hebebrand, Marvin Grabler, Jochen Antel, University of Zurich, and Antel, Jochen

Subjects
medicine.medical_specialty, Pediatrics, Medizin, 610 Medicine & health, Anorexia nervosa, Hypogonadotropic hypogonadism, Metreleptin, 03 medical and health sciences, chemistry.chemical_compound, 2738 Psychiatry and Mental Health, 0302 clinical medicine, Rating scale, medicine, Child and adolescent psychiatry, Developmental and Educational Psychology, Antidepressive, 0501 psychology and cognitive sciences, Dosing, 2735 Pediatrics, Perinatology and Child Health, Libido, 3204 Developmental and Educational Psychology, business.industry, 05 social sciences, General Medicine, Original Contribution, Perinatology and Child Health, medicine.disease, Hyperactivity, Psychiatry and Mental health, Mood, 10057 Klinik für Konsiliarpsychiatrie und Psychosomatik, chemistry, Pediatrics, Perinatology and Child Health, business, 030217 neurology & neurosurgery, 050104 developmental & child psychology
Abstract

With this case report we support our medical hypothesis that metreleptin treatment ameliorates starvation related emotional, cognitive and behavioral symptomatology of anorexia nervosa (AN) and show for the first time strong effects in a male patient with AN. A 15.9 year old adolescent with severe AN of eight-month duration was treated off-label with metreleptin. Hyperactivity was assessed with accelerometry. Visual analogue scales (VAS), validated self- and clinician rating scales and lab results tracked changes from baseline to end of the 24-day dosing period and a five-month follow-up. Substantial improvements of mood and eating disorder related cognitions and hyperactivity set in after two days of treatment. During dosing, sub-physiological testosterone and TT3 levels normalized; clinically libido reemerged. Weight did not increase substantially during the dosing period. During follow-up target weight was attained; mood did not deteriorate; hyperactivity ceased. The results substantiate the strong effects seen in female cases and underscore the need for a double-blind placebo-controlled trial to confirm the observed strong, multiple and rapid onset beneficial effects of metreleptin in AN. Supplementary Information The online version contains supplementary material available at 10.1007/s00787-021-01778-7.

Published
2021

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