1. Effect of transtympanic betamethasone delivery to the inner ear
- Author
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Fatih Özdoğan, Selahattin Genç, Seren Gülşen Gürgen, Halil Erdem Özel, Adin Selcuk, and Erkan Esen
- Subjects
Male ,medicine.medical_specialty ,Tympanic Membrane ,Otoacoustic Emissions, Spontaneous ,Otoacoustic emission ,Apoptosis ,Betamethasone ,Andrology ,03 medical and health sciences ,0302 clinical medicine ,Ototoxicity ,In Situ Nick-End Labeling ,medicine ,Animals ,Inner ear ,Rats, Wistar ,030223 otorhinolaryngology ,Glucocorticoids ,Organ of Corti ,Spiral ganglion ,Caspase 8 ,TUNEL assay ,Caspase 3 ,business.industry ,General Medicine ,medicine.disease ,Cochlea ,Rats ,Surgery ,Hair Cells, Auditory, Outer ,medicine.anatomical_structure ,Otorhinolaryngology ,Terminal deoxynucleotidyl transferase ,Ear, Inner ,Sensory Thresholds ,sense organs ,Gentamicins ,Spiral Ganglion ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
To investigate the effect of transtympanic betamethasone administration on hearing function with histologic correlation, rats were divided into three transtympanic treatment groups: isotonic saline (group I, n = 10), gentamicin (group II, n = 10) and betamethasone (group III, n = 10). Distortion product otoacoustic emission thresholds were compared on day 10. Also histological effects on cellular apoptosis in both the inner and outer hair cells in organ of Corti and spiral ganglion neurons were evaluated. Distortion product otoacoustic emission thresholds were comparable (p > 0.05) between group I and group III in all measurements. Distortion product otoacoustic emission thresholds of group II were significantly elevated in all measurements when compared with group I (p
- Published
- 2016
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