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Aim:Renal colic is a urological emergency usually caused by urolithiasis and manifested by severe pain. Emergency treatment’s main purpose is to effectively relieve pain and urinary obstruction without impaired renal function. We measured the efficacy and safety of intravenous ibuprofen on renal colic pain.Materials and Methods:Two-hundred thirty-five patients who were admitted to the emergency department between 01.01.2016-30.06.2017 and were suspected of renal colic that scored at least 2 points on the visual analog scale (VAS) or FLACC scale were included in the study after obtaining detailed consent. One hundred-fifty four patients whose diagnoses were confirmed radiologically, included in the study as Group A (dexketoprofen) (n=35), Group B (ibuprofen 400 mg) (n=37), Group C (ibuprofen 800 mg) (n=44), and Group D (fentanyl) (n=38). VAS and FLACC scales were re-evaluated on the 20th, 40th, and 60th minutes after drug administration.Results:64.9% of the patients were male and 35.1% were female, and the mean age was 42.31 (±15.46). It was observed that all 4 of the medications given to patients who applied to the emergency department with flank pain provided effective analgesia, but the drugs could not establish a statistically significant advantage over each other.Conclusion:Intravenous administration of ibuprofen is considered as an effective and safe alternative in the treatment of renal colic pain in the emergency department.