1. Cancer research in the era of immunogenomics
- Author
-
Yochai Wolf and Yardena Samuels
- Subjects
0301 basic medicine ,Cancer Research ,Human leucocyte antigen ,business.industry ,medicine.medical_treatment ,Immune checkpoint inhibitors ,Cancer ,Immunotherapy ,Review ,immunogenomics ,Bioinformatics ,medicine.disease ,3. Good health ,Cancer treatment ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,medicine ,business - Abstract
The most meaningful advancement in cancer treatment in recent years has been the emergence of immunotherapy. Checkpoint inhibitor blockade and adoptive T cell therapy have shown remarkable clinical effects in a wide range of tumour types. Despite these advances, many tumours do not respond to these treatments, which raises the need to further investigate how patients can benefit from immunotherapy. This effort can now take advantage of the recent technological progress in single-cell, high-throughput sequencing and computational efforts. In this review, we will discuss advances in different immunotherapies and the principles of cancer immunogenomics, with an emphasis on the detection of cancer neoantigens with human leucocyte antigen peptidomics, and how these principles can be further used for more efficient clinical output.
- Published
- 2018