1. Identification of novel circulating microRNAs in advanced heart failure by next‐generation sequencing
- Author
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Alessandro Galluzzo, Simona Gallo, Barbara Pardini, Giovanni Birolo, Piero Fariselli, Paolo Boretto, Annapia Vitacolonna, Caterina Peraldo‐Neia, Martina Spilinga, Alessandra Volpe, Dario Celentani, Stefano Pidello, Alessandro Bonzano, Giuseppe Matullo, Carla Giustetto, Serena Bergerone, and Tiziana Crepaldi
- Subjects
Biomarkers ,Circulating microRNAs ,Heart failure ,Risk stratification ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims Risk stratification in patients with advanced chronic heart failure (HF) is an unmet need. Circulating microRNA (miRNA) levels have been proposed as diagnostic and prognostic biomarkers in several diseases including HF. The aims of the present study were to characterize HF‐specific miRNA expression profiles and to identify miRNAs with prognostic value in HF patients. Methods and results We performed a global miRNome analysis using next‐generation sequencing in the plasma of 30 advanced chronic HF patients and of matched healthy controls. A small subset of miRNAs was validated by real‐time PCR (P
- Published
- 2021
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