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Start Over Author "Yuan Neng" Journal epilepsy research
2 results on '"Yuan Neng"'

2. Absence of linkage to 8q23.3-q24.1 and 2p11.1-q12.2 in a new BAFME pedigree in China: indication of a third locus for BAFME

Author

Su-Mei Xiao, Fei-Yan Deng, Hong-Wen Deng, Bo Xiao, Yun-Ci Zhang, Jian Gong, Shu-Feng Lei, Xiang-Ding Chen, Yuan-Neng Li, and Kang Wang

Subjects
Genetics, Adult, Male, Benign adult familial myoclonic epilepsy, China, Genotype, Genetic heterogeneity, Chromosome Mapping, Locus (genetics), Pedigree chart, Electroencephalography, Epilepsies, Myoclonic, Biology, Pedigree, Neurology, Genetic linkage, Chromosome regions, Chromosomes, Human, Pair 2, Microsatellite, Humans, Female, Neurology (clinical), Genotyping, Chromosomes, Human, Pair 8, Retrospective Studies
Abstract

Benign adult familial myoclonic epilepsy (BAFME) were mapped on chromosome 8q24 and 8q23.3-q24.1 in Japanese pedigrees and mapped on 2p11.1-2q12.2 in European pedigrees, respectively. Recently, we recruited a large BAFME pedigree in China. After genotyping 11 microsatellite markers covering the two previously identified chromosome regions, we performed linkage analyses. However, evidence of negative linkage was found in the two previously reported candidate regions (LOD score-3.0 at no recombination). Our data suggest that the causative gene responsible for BAFME in the Chinese pedigree may be located on a new region other than 8q23.3-q24.1 and 2p11.1-q12.2, indicating the presence of a third locus for BAFME.

Published
2005

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