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• Gaps between recommended and implemented care are common in status epilepticus (SE). • Studying and closing these gaps will require systematic study and focused efforts. • Implementation science (IS) employs a mixed methods approach, identifying factors that impact uptake across multiple levels. • A multipronged approach leveraging IS methods will require better integration of real-world and research infrastructure, clinical data harmonization, revision of funding priorities, regulatory reform to promote practice-based evidence and the formation of transdisciplinary teams and learning collaboratives. Status epilepticus (SE) is a time-sensitive, potentially life-threatening neuro-emergency associated with poor functional outcomes and increased hospital resource utilization especially when it progresses to refractory or super-refractory forms. Timely recognition & treatment improves outcomes, however gaps between recommended and implemented care are common and pervasive. This review provides a roadmap for incorporating the relatively new field of Implementation Science in promoting the systematic uptake of evidence-based practices into the real-world care of patients with SE. A multifaceted approach − including better integration of real-world implementation and research infrastructure, an emphasis on standardizing and harmonization clinical data, re-examining funding priorities, regulatory reform, and the formation of transdisciplinary teams and learning collaboratives − has the potential to advance the care of patients in SE from its current status quo. This topic was presented at the 9th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures held in April 2024. [ABSTRACT FROM AUTHOR]

Lessons learned from the Rapid Anticonvulsant Medication Prior to Arrival Trial (RAMPART) and Established Status Epilepticus Treatment Trial (ESETT) trials are considered in three ways. First, by asking about the questions the trials were primarily designed to answer, then about the context of the intervention and characteristics of the patients described in secondary analyses, and finally, about what was learned about how to conduct trials in this space. The talk concludes with suggestions and a vision for how to best conduct future trials investigating status epilepticus. This paper was presented at the 8th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures held in September 2022. [ABSTRACT FROM AUTHOR]

This paper describes the 5th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures held in London on April 9–11 2015. It reviews the progress made in this field since 2007, when the first London-Innsbruck Colloquium was held, and the program of the 2015 meeting. This article is part of a Special Issue entitled “Status Epilepticus”. [ABSTRACT FROM AUTHOR]