15 results on '"Youssef, G."'
Search Results
2. Histopathological Correlates of Epileptogenicity as Expressed by Electrocorticographic Spiking and Seizure Frequency
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Rosenow, Felix, Lüders, Hans O., Dinner, Dudley S., Prayson, Richard A., Mascha, Edward, Wolgamuth, Barbara R., Comair, Youssef G., and Bennett, Gregory
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- 1998
3. Neuropsychological Effect of Temporal Lobe Resection in Preadolescent Children with Epilepsy
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Szabó, C. Akos, Wyllie, Elaine, Stanford, Lisa D., Geckler, Cheri, Kotagal, Prakash, Comair, Youssef G., and Thornton, Allen E.
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- 1998
4. Epilepsy Surgery in Infants
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Wyllie, Elaine, Comair, Youssef G., Kotagal, Prakash, Raja, Shanker, and Ruggieri, Paul
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- 1996
5. Normalization of Quality of Life Three Years after Temporal Lobectomy: A Controlled Study
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Mohamad A. Mikati, Amal C. Rahi, and Youssef G. Comair
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Health Status ,Population ,Disease-Free Survival ,Temporal lobe ,Central nervous system disease ,Epilepsy ,Surveys and Questionnaires ,Adaptation, Psychological ,Preoperative Care ,medicine ,Humans ,Epilepsy surgery ,Longitudinal Studies ,Lebanon ,education ,education.field_of_study ,Seizure frequency ,Temporal lobectomy ,Anterior Temporal Lobectomy ,medicine.disease ,humanities ,Arabs ,Surgery ,Treatment Outcome ,Epilepsy, Temporal Lobe ,Neurology ,Quality of Life ,Anticonvulsants ,Female ,Neurology (clinical) ,Diterpenes ,Psychology ,Social Adjustment ,Intractable seizures ,Follow-Up Studies - Abstract
Summary: Purpose: The goal of epilepsy surgery is not merely to control previously intractable seizures, but also to improve quality of life (QOL). Our goals were to assess, in our Middle Eastern population, the QOL of adults with temporal lobe epilepsy (TLE) 3 years after temporal lobectomy as compared with matched TLE patients who did not undergo surgery and with healthy individuals in the same community. Methods: Twenty consecutive TLE patients who underwent temporal lobectomy 3 years previously were matched in the following variables: age, sex, seizure frequency, seizure duration, age at onset of epilepsy, duration of epilepsy, and number of medications, with 17 TLE patients who underwent the presurgical evaluation and subsequent optimization of medical therapy but did not undergo surgery. They were also matched for age, sex, educational level, income, and residence with 20 healthy individuals. All groups were interviewed by using the ESI-55 questionnaire. Results: Compared with the nonsurgery group, QOL was significantly better in the surgery group (85% seizure free) in the well-being, functioning, and role-limitation domains. QOL was similar in the surgery and healthy control groups in all domains and scales. The nonsurgery group scored significantly lower than healthy controls in the functioning and role-limitation domains. Conclusions: Intractable TLE was associated with marked impairments in QOL despite continued attempts to optimize medical therapy. Three years after temporal lobectomy QOL in our patient population achieved levels similar to those of matched healthy individuals. To our knowledge, this is the first study to report normalization of QOL after temporal lobectomy, in any population. Key Words: QOL—temporal lobe epilepsy— Lobectomy.
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- 2006
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6. Neuropsychological Effect of Temporal Lobe Resection in Preadolescent Children with Epilepsy
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Allen E. Thornton, Youssef G. Comair, Lisa D. Stanford, Elaine Wyllie, Cheri Geckler, Prakash Kotagal, and C. Ákos Szabó
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Neuropsychological Tests ,Electroencephalography ,Functional Laterality ,Temporal lobe ,Central nervous system disease ,Epilepsy ,medicine ,Humans ,Epilepsy surgery ,Child ,Intelligence Tests ,Memory Disorders ,medicine.diagnostic_test ,Brain Neoplasms ,Age Factors ,Neuropsychology ,Cognition ,Neuropsychological test ,medicine.disease ,Magnetic Resonance Imaging ,Temporal Lobe ,Surgery ,Treatment Outcome ,Epilepsy, Temporal Lobe ,Neurology ,Female ,Neurology (clinical) ,Cognition Disorders ,Psychology ,Follow-Up Studies - Abstract
Summary: Purpose: Numerous studies have demonstrated changes in cognitive, memory, and language functioning in adults and adolescents after temporal lobectomy, yet little information is available regarding neuropsychological outcome in preadolescent children. Methods: We studied pre-and postoperative neuropsychological test results from 14 children who underwent temporal lobe resection for intractable epilepsy at age 7–12 years (mean 9.4 years). Results: Thirteen patients (93%) had no seizures or less than one seizure a year at follow-up 23-48 months (mean 34 months) after operation. Postoperative neuropsychological testing was performed 6–9 months (mean 7 months) after surgery in 13 patients and 36 months after the first operation in 1 patient who underwent two-stage resection of a tumor. Verbal, Performance, and Full Scale IQ were initially in the low-average range, with no significant change across the pre-and postoperative evaluations. Immediate verbal memory performance decreased significantly in children who initially performed above the median preoperatively and tended to decrease in children who had left rather than right temporal lobe resection. Significant postoperative decreases in delayed memory scores were independent of preoperative ability or side of resection. Conclusions: Our small study suggests vulnerability to postoperative decline in immediate verbal memory scores in preadolescent children who have higher baseline immediate memory function or undergo left rather than right temporal lobe resection, similar to that observed in adolescents in adults. The entire group exhibited a statistically significant decrease in delayed verbal memory. Study of larger series of patients will be important to clarify further the short-and long-term risks and benefits of temporal lobe resection in childhood.
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- 1998
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7. MRS Metabolic Markers of Seizures and Seizure-Induced Neuronal Damage
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Youssef G. Comair, Thian C. Ng, Hans Lüders, Imad Najm, D. Shedid, and Yang Wang
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Male ,medicine.medical_specialty ,Kainic acid ,Pathology ,Magnetic Resonance Spectroscopy ,Cell Count ,Status epilepticus ,Biology ,Cycloheximide ,Hippocampus ,Choline ,Rats, Sprague-Dawley ,Epilepsy ,chemistry.chemical_compound ,symbols.namesake ,Status Epilepticus ,Seizures ,Internal medicine ,medicine ,Animals ,Premovement neuronal activity ,Hippocampus (mythology) ,Ictal ,Neurons ,Aspartic Acid ,Kainic Acid ,Brain ,Creatine ,medicine.disease ,Rats ,Endocrinology ,nervous system ,Neurology ,chemistry ,Lactates ,Nissl body ,symbols ,Neurology (clinical) ,medicine.symptom ,Biomarkers - Abstract
Summary: Purpose: Proton magnetic resonance spectroscopy (MRS) was used to identify specific in situ metabolic markers for seizures and seizure-induced neuronal damage. Kainic acid (KA)-induced seizures lead to histopathologic changes in rat brain. The protective effect of cycloheximide treatment against neuronal damage caused by KA-induced seizures was studied, using in situ proton MRS imaging technique. Methods: Rats were pretreated with placebo or cycloheximide 1 h before KA injection. Rat brains (n = 25) were scanned at the level of the hippocampus before, during, and 24 h after seizures. Spectra were recorded and the relative ratios of N-acetylaspartate (NAA), choline (cho), and lactate (Lac) to creatine (Cr) were calculated and compared between groups. Results: A significant increase in Lac ratios was observed in KA-treated rats during and 24 h after seizure onset and this increase was prevented by cycloheximide pretreatment. NAA ratios were significantly higher during the ictal phase following KA treatment and this effect was not affected by cycloheximide pretreatment. Nissl staining confirmed previously reported prevention of KA-induced neuronal loss in CA1 and CA areas of the hippocampus by cycloheximide pretreatment. Conclusions: Our results suggest that in situ Lac increase is a marker of seizure-induced neuronal damage, whereas N-acetylaspartate (NAA) changes during and after status epilepticus may be a reflection of neuronal activity and damage, respectively.
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- 1998
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8. Postictal Alteration of Sodium Content and Apparent Diffusion Coefficient in Epileptic Rat Brain Induced by Kainic Acid
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Anthony W. Majors, Thian C. Ng, Min Xue, Youssef G. Comair, Imad Najm, Yang Wang, and Michael T. Modic
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Intracellular Fluid ,medicine.medical_specialty ,Kainic acid ,Sodium ,chemistry.chemical_element ,Hippocampus ,Temporal lobe ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Edema ,Internal medicine ,medicine ,Animals ,Humans ,Effective diffusion coefficient ,Brain Chemistry ,Kainic Acid ,medicine.diagnostic_test ,Chemistry ,business.industry ,Putamen ,Brain ,Magnetic resonance imaging ,Olfactory Pathways ,Amygdala ,Isotopes of sodium ,Magnetic Resonance Imaging ,Rats ,body regions ,Disease Models, Animal ,Ion homeostasis ,Endocrinology ,Epilepsy, Temporal Lobe ,Neurology ,Sodium Isotopes ,Neurology (clinical) ,medicine.symptom ,Extracellular Space ,Nuclear medicine ,business - Abstract
Summary: Purpose: We studied temporal changes of brain sodium and apparent diffusion coefficient (ADC) in a temporal lobe epilepsy (TLE) rat model using kainic acid (KA). Methods: In situ three-dimensional 23Na magnetic resonance imaging (MRI) and proton diffusion-weighted imaging (DWI) were used. KA at a dose of 10 mg/kg body weight and 12 adult Sprague Dawley rats weighing 228–318 g (268 ± 25 g) were used. Results: Twenty-four hours after KA injection, magnetic resonance (MR) visible sodium levels increased in both the pyriform cortex (+90%) and amygdala (+68%) and increased insignificantly in the hippocampus (+18%) and caudate-putamen (12%). The ADC in the pyriform cortex showed a −9% decrease at 5 h postictally, reaching −30% at 24 h, whereas in the amygdala decreases were −8 and −26% respectively. A significant decrease in ADC (−7%) in the hippocampus was also observed 24 h postically. Seven days later, sodium increases persisted, whereas ADC returned to normal level. Conclusions: The increase in MR visible sodium, associated with the decrease in ADC is consistent with the hypothesis that sequential seizures caused an increase in sodium influx and perturbation of membrane ion homeostasis, which eventually evolved into an irreversible phase of cellular edema, with increased MR visible intracellular sodium and decreased ADC. Return of ADC to near-control level and persistent high sodium level at 7 days may be explained by the increase in extracellular space and tissue necrosis.
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- 1996
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9. Epilepsy Surgery in Infants
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Shanker Raja, Elaine Wyllie, Youssef G. Comair, Prakash Kotagal, and Paul Ruggieri
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Male ,Reoperation ,medicine.medical_specialty ,Hemimegalencephaly ,medicine.medical_treatment ,Epilepsy ,Sturge-Weber Syndrome ,medicine ,Humans ,Ictal ,Epilepsy surgery ,Age of Onset ,Ganglioglioma ,Cerebral Cortex ,Brain Neoplasms ,business.industry ,Age Factors ,Brain ,Infant ,Electroencephalography ,Cortical dysplasia ,medicine.disease ,Magnetic Resonance Imaging ,Hypsarrhythmia ,Surgery ,Hemispherectomy ,Treatment Outcome ,Hemiparesis ,Neurology ,Child, Preschool ,Anesthesia ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Spasms, Infantile ,Follow-Up Studies ,Tomography, Emission-Computed - Abstract
Summary: Purpose: We report 12 infants who had frontal (n = 3), temporal (n = 2), or temporoparieto-occipital (n = 2) resection or functional hemispherectomies (n = 5) at age 2.5–29 (mean 15.3) months for catastrophic epilepsy due to focal cortical dysplasia (n = 5), Sturge-Weber syndrome (n = 3), ganglioglioma (n = 3), or hemimegalencephaly (n = 1). Seizures began at 1 day to 14 months (mean, 4.0 months) after birth, occurred frequently (often many times per day, and were refractory to antiepileptic drugs. Patients were evaluated for surgery at 2.5–24 (mean 12.4) months of age. Seven patients had hemiparesis and eight had slowed cognitive development. Seizures were characterized by arrest or marked reduction of behavioral motor activity with unclear level of consciousness (n = 4, with temporal or temporoparietal EEG seizures), focal clonic activity (n = 3, with perirolandic EEG seizures), generalized tonic stiffening (n = 3, with temporoparieto-occipital, parietal, or frontal EEG seizures), or infantile spasms and hypsarrhythmia (n = 2, with a frontal tumor or temporoparieto-occipital cortical dysplasia). Methods: Magnetic resonance imaging (MRI) revealed the epileptogenic lesion in all but two patients, both with cortical dysplasia localized by interictal positron-emission tomography (PET) and other clinical or EEG features and confirmed on histopathologic examination of resected tissue. Results: At follow-up 4-86 (mean 32) months after surgery, six patients were seizure free (Engel outcome class I), three had rare seizures with none in at least the previous 6 months (Engel class II), and two had worthwhile improvement (Engel class III). Except for the severely developmentally delayed infant with hemimegalencephaly, several patients had marked “catch-up” developmental progress after class I, 11, or III outcome. Postoperative complications included subdural hematoma over the contralateral hemisphere (one patient) and entrapment and enlargement of the ipsilateral temporal horn (one patient) after hemispherectomy, both corrected uneventfully with a second surgical procedure. One patient died of unexplained causes several hours after frontal lobectomy. No patients had new neurologic deficits after surgery, and one patient had resolution of progressive fluctuating hemiparesis after resection of temporoparieto-occipital cortical dysplasia. Conclusions: Our results agree with previous reports that epilepsy surgery can provide relief from catastrophic epilepsy in carefully selected infants.
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- 1996
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10. Surgery for Intractable Infantile Spasms: Neuroimaging Perspectives
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Harry V. Vinters, Raman Sankar, Youssef G. Comair, W. D. Shields, Warwick J. Peacock, Harry T. Chugani, and D. A. Shewmon
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Deoxyglucose ,Epilepsy ,Neuroimaging ,Fluorodeoxyglucose F18 ,Monitoring, Intraoperative ,medicine ,Humans ,Ictal ,Cerebral Cortex ,medicine.diagnostic_test ,Seizure types ,business.industry ,Brain ,Infant ,Electroencephalography ,Magnetic resonance imaging ,Cortical dysplasia ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,Hemispherectomy ,Glucose ,Neurology ,Child, Preschool ,Female ,Neurology (clinical) ,Neurosurgery ,business ,Spasms, Infantile ,Follow-Up Studies ,Tomography, Emission-Computed - Abstract
Twenty-three infants and children underwent cortical resection (n = 15) or hemispherectomy (n = 8) for intractable infantile spasms. Infantile spasms were present at the time of surgery in 17 of the 23 patients; in six, spasms had evolved to other seizure types during surgical evaluation. Children with a remote history of infantile spasms were excluded from this study. Focal or hemispheric lesions were identified by magnetic resonance imaging in seven children; an additional two showed focal atrophy without a discrete lesion. Positron emission tomography (PET) showed lateralized or localized abnormalities of cerebral glucose utilization in all patients; in 14, PET was the only neuroimaging modality to identify the epileptogenic cortex. When this occurred, neuropathological examination of resected brain tissue typically showed malformative and dysplastic cortical lesions. Focal interictal and/or ictal electrographic abnormalities were present in all patients, and corresponded well with localization from neuroimaging. None of the patients were subjected to chronic invasive electrographic monitoring with intracranial electrodes. At follow-up (range 4-67 months; mean 28.3 months), 15 children were seizure-free, three had 90% seizure control, one had 75% seizure control, and four failed to benefit from surgery with respect to seizure frequency.
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- 1993
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11. Histopathological correlates of epileptogenicity as expressed by electrocorticographic spiking and seizure frequency
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Barbara R. Wolgamuth, Edward J. Mascha, Youssef G. Comair, Dudley S. Dinner, Hans Lüders, Felix Rosenow, Gregory Bennett, and Richard A. Prayson
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Adult ,medicine.medical_specialty ,Pathology ,Adolescent ,Pilot Projects ,Ganglioglioma ,Central nervous system disease ,Epilepsy ,Glioma ,medicine ,Humans ,Age of Onset ,Child ,neoplasms ,Electrocorticography ,Cerebral Cortex ,medicine.diagnostic_test ,business.industry ,Brain Neoplasms ,Brain ,Infant ,Electroencephalography ,Cortical dysplasia ,Middle Aged ,medicine.disease ,Treatment Outcome ,Neurology ,Dysplasia ,Child, Preschool ,Histopathology ,Neurology (clinical) ,Epilepsies, Partial ,business - Abstract
Summary: Purpose: To study the correlation between histopathology and epileptogenicity, as measured by seizure frequency and electrocorticography (EcoG), in patients with cortical dysplasia (CD) as compared with control patients with gangliogliomas or gliomas. Methods: The influence of the histopathological classification and the presence of balloon cells in CD on the frequency and extension of five predefined patterns of ECoG spiking, seizure frequency, age of seizure onset and 6-month postoperative outcome were analyzed in 32 patients with focal epilepsy undergoing presurgical evaluation with chronically implanted subdural electrodes. Results: Comparison of patients with CD, gangliogliomas, and gliomas showed that the seizure frequency was greatest in patients with CD and ECoG spiking and was most extensive in patients with gangliogliomas. The onset of epilepsy was earlier in patients with CD and with gangliogliomas. None of these differences was significant. However, in patients with CD, the presence of balloon cells was associated with significantly greater seizure frequency (p = 0.009), and a significantly greater number of electrodes recording continuous frequent spiking (p = 0.03). The presence of continuous very frequent spiking correlated with the duration of the epilepsy and the number of seizures recorded during monitoring. No significant correlation was detected between histopathology, seizure frequency, or ECoG activity and postoperative outcome, which was relatively favorable in patients with balloon cells. Conclusions: CD refers to a variety of histopathological patterns associated with different epileptogenicity. In CD, increased clinical and ECoG epileptogenicity correlates with the presence of balloon cells. This finding confirms that balloon cells should be considered in the histopathological classification of CD. The predefined ECoG were not specific for any of the histopathologies investigated.
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- 1998
12. Temporal changes in proton MRS metabolites after kainic acid-induced seizures in rat brain
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S. C. Hong, Youssef G. Comair, Thian C. Ng, Hans Lüders, Imad Najm, and Yang Wang
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Male ,medicine.medical_specialty ,Kainic acid ,Magnetic Resonance Spectroscopy ,Excitotoxicity ,Cell Count ,Hippocampal formation ,medicine.disease_cause ,Creatine ,Hippocampus ,Choline ,Rats, Sprague-Dawley ,Epilepsy ,chemistry.chemical_compound ,Seizures ,Internal medicine ,medicine ,Animals ,Ictal ,Lactic Acid ,Aspartic Acid ,Kainic Acid ,Neuropeptides ,Glutamate receptor ,Brain ,Dipeptides ,medicine.disease ,Temporal Lobe ,Rats ,Disease Models, Animal ,Endocrinology ,nervous system ,Neurology ,chemistry ,Epilepsy, Temporal Lobe ,Anesthesia ,Creatinine ,Neurology (clinical) ,Protons - Abstract
Summary: Purpose: In situ 1H-magnetic resonance spectroscopy (MRS) was used to study temporal metabolic changes in a rat model of temporal lobe epilepsy (TLE) by using kainic acid (KA). Methods: Rat brains were scanned at the level of the hippocampal body for MRS measurements. Relative ratios of N- acetyl groups (NA: N-acetylaspartate and N-acetylaspartyl glutamate), choline, and lactate (Lac) over creatine (Cr) were calculated. Results: NA/Cr ratios increased significantly during the ictal phase. During the postictal and interictal phases, the NA/Cr ratio decreased. There was a significant and prolonged increase of the lactate/Cr ratio in the hippocampi of rats that started 1 h after the onset of KA-induced seizure activity and persisted up to 24 h after the injection. The prolonged lactate/Cr increase in an area susceptible to neuronal damage (e.g., hippocampus) correlated with the onset of seizure activity but remained elevated thereafter. Conclusions: The ictal and early postictal increase in lactate ratios may reflect increased cellular activity and metabolism resulting from KA excitotoxicity. Assuming that the changes in NA/Cr ratios are due to NAA increase, we speculate that an activation of the N-acetylaspartylglutamate (NAAG) dipeptidase pathway may explain the ictal increase in NA/Cr ratios. The late postictal decrease in NNCr ratios is a reflection of KA-induced neuronal cell loss.
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- 1997
13. Subdural recording of ictal DC shifts in neocortical seizures in humans
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Waro Taki, Akio Ikeda, Hiroshi Shibasaki, Kiyohito Terada, Nobuhiro Mikuni, Richard C. Burgess, Youssef G. Comair, Toshiaki Hamano, Jun Kimura, and Hans Lüders
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Adult ,Male ,Adolescent ,Subdural Space ,Electroencephalography ,Functional Laterality ,Central nervous system disease ,Epilepsy ,Medicine ,Animals ,Humans ,Ictal ,In patient ,Monitoring, Physiologic ,Cerebral Cortex ,Brain Mapping ,medicine.diagnostic_test ,business.industry ,Ictal eeg ,Middle Aged ,medicine.disease ,Electric Stimulation ,nervous system diseases ,Electrodes, Implanted ,Electrophysiology ,nervous system ,Neurology ,Negative potential ,Female ,Neurology (clinical) ,Epilepsies, Partial ,business ,Subdural electrodes ,Neuroscience - Abstract
Summary: Purpose: Invasive ictal EEG recording is often necessary to delineate epileptogenic areas in patients with intractable partial epilepsy, but even intracranial ictal recordings often reveal ill-defined onset zones in neocortical epilepsy. We studied the physiologic significance of ictal direct current (DC) potentials recorded intracranially in human epilepsy. Methods: We made intracranial ictal EEG recordings in three patients with intractable partial seizures arising from frontal, lateral temporal, and parietal neocortical areas by using closely spaced subdural electrodes (platinum in two patients and stainless steel in one patient) with both standard (1.5 Hz) and open (0.016 Hz) low-frequency filter (LFF) settings. Results: The initial ictal pattern was localized to two to nine subdural electrodes and characterized by very low voltage and high-frequency rhythmic activity (“electrode-cremental pattern”). A slow-rising negative potential (DC potential) was seen in a slightly more restricted area (two to six electrodes) and occurred 1–10 s before the initial ictal EEG discharges in two patients. Conclusions: These results agree with those of previous studies of ictal DC shifts in animals and suggest that ictal DC shifts may be helpful in delineating the epileptogenic area more precisely in human epilepsy.
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- 1996
14. Temporal lobe epilepsy in early childhood
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Youssef G. Comair, Elaine Wyllie, Melinda L. Estes, Prakash Kotagal, Margaret Pizzi, Hans Lüders, Michael W. L. Chee, Marja-Liisa Granström, Blaise F. D. Bourgeois, Ennio DelGiudice, Wyllie, E, Chee, M, Granstrom, Ml, DEL GIUDICE, Ennio, Estes, M, Comair, Y, Pizzi, M, Kotagal, P, Bourgeois, B, and Luders, H.
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medicine.medical_specialty ,Electroencephalography ,Audiology ,Temporal lobe ,Epilepsy ,medicine ,Humans ,Ictal ,Child ,Cerebral Cortex ,Brain Diseases ,Sclerosis ,medicine.diagnostic_test ,Brain Neoplasms ,Age Factors ,Infant ,Videotape Recording ,Cortical dysplasia ,Semiology ,medicine.disease ,Magnetic Resonance Imaging ,Temporal Lobe ,medicine.anatomical_structure ,Treatment Outcome ,Neurology ,Epilepsy, Temporal Lobe ,Anesthesia ,Scalp ,Child, Preschool ,Neurology (clinical) ,Neurosurgery ,Psychology - Abstract
To explore the electroclinical features of temporal lobe epilepsy (TLE) in early childhood, we studied results of video-EEG and other tests of 14 children aged 16 months to 12 years selected by seizure-free outcome after temporal lobectomy. Four children had mesiotemporal sclerosis, 1 had cortical dysplasia, and 9 had low-grade temporal neoplasms. The children had complex partial seizures (CPS) with symptomatology similar to that of adults with TLE, including decreased responsiveness and automatisms. Automatisms tended to be simpler in the younger children, typically limited to lip smacking and fumbling hand gestures. Scalp/sphenoidal EEG showed anterior/inferior temporal interictal sharp waves and unilateral temporal seizure onset in the 4 children with mesiotemporal sclerosis and in the child with cortical dysplasia, but EEG findings in 9 children with low-grade temporal tumors were complex, including multifocal interictal sharp waves or poorly localized or falsely lateralized EEG seizure onset. In children without tumors, video-EEG was critical to localization of the epileptogenic zone for resection, but in patients with tumors video-EEG was less localizing and its main value was to confirm that the reported behaviors were epileptic seizures with semiology typical of temporal lobe onset.
- Published
- 1993
15. Neurosurgical Treatment of Refractory Status Epilepticus
- Author
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Gorman, David G., primary, Shields, W. Donald, additional, Shewmon, D. Alan, additional, Chugani, Harry T., additional, Finkel, Richard, additional, Comair, Youssef G., additional, and Peacock, Warwick J., additional
- Published
- 1992
- Full Text
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