1. Therapeutic time window of low-frequency stimulation at entorhinal cortex for amygdaloid-kindling seizures in rats
- Author
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Zheng-Hao, Xu, Deng-Chang, Wu, Qi, Fang, Kai, Zhong, Shuang, Wang, Hong-Liu, Sun, Shi-Hong, Zhang, and Zhong, Chen
- Subjects
Male ,Epilepsy ,Time Factors ,Deep Brain Stimulation ,Electric Stimulation Therapy ,Electroencephalography ,Amygdala ,Electric Stimulation ,Functional Laterality ,Electrodes, Implanted ,Rats ,Rats, Sprague-Dawley ,Disease Models, Animal ,Seizures ,Kindling, Neurologic ,Animals ,Entorhinal Cortex - Abstract
The present study was designed to determine whether low-frequency stimulation (LFS) of the entorhinal cortex(EC) has an anticonvulsive effect, and whether LFS delivered at different times plays different roles. We found that LFS of the EC immediately or 4 s after kindling stimulation had an anticonvulsive effect, and that the latter had a better effect on both kindling and kindled seizures. However, LFS delivered after the cessation of afterdischarge or 10 s after the kindling stimulation, augmented the epileptic activity. So the EC is a potential target for LFS to interfere with epilepsy. Our findings suggest that even in the duration of afterdischarge, there exists a "time window" for LFS treatment, indicating that the time delay of closed-loop stimulation is crucial for LFS treatment.
- Published
- 2010