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Your search keyword '"Parvaneh Ebrahimi"' showing total 2 results
Start Over Author "Parvaneh Ebrahimi" Journal epigenetics
2 results on '"Parvaneh Ebrahimi"'

1. Epigenome-wide cross-tissue correlation of human bone and blood DNA methylation – can blood be used as a surrogate for bone?

Author

Parvaneh Ebrahimi, Holger Luthman, Fiona E McGuigan, and Kristina E Akesson

Subjects
dna methylation, bone, blood, epigenetics, surrogate tissue, Genetics, QH426-470
Abstract

Difficulty in obtaining bone tissue is an obstacle to studying epigenetics to understand gene–environment interactions, and their role in disease pathogenesis. Blood is an obvious alternative and in this proof of principle study, our aim was to systematically investigate whether blood is a viable surrogate for bone. We measured epigenome-wide DNA methylation at 850 K CpG sites in matched trabecular bone and peripheral blood collected from the same patients at the same time-point (n = 12 women; 66–85y), to investigate the between-tissue correspondence. What constituted a CpG site with corresponding methylation in both tissues was stringently defined. Only sites highly correlated (r2 > 0.74; FDR q-value

Published
2021
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2. Epigenome-wide cross-tissue correlation of human bone and blood DNA methylation - can blood be used as a surrogate for bone?

Author

Holger Luthman, Kristina Åkesson, Parvaneh Ebrahimi, and Fiona E. McGuigan

Subjects
0301 basic medicine, Cancer Research, Human bone, Biology, Disease pathogenesis, Bioinformatics, Bone tissue, bone, Bone and Bones, 03 medical and health sciences, Epigenome, 0302 clinical medicine, blood, medicine, Humans, surrogate tissue, Epigenetics, Molecular Biology, Aged, Aged, 80 and over, Blood Cells, DNA methylation, epigenetics, 030104 developmental biology, medicine.anatomical_structure, Genetic Loci, Organ Specificity, 030220 oncology & carcinogenesis, CpG Islands, Female, Research Article, Research Paper
Abstract

Difficulty in obtaining bone tissue is an obstacle to studying epigenetics to understand gene–environment interactions, and their role in disease pathogenesis. Blood is an obvious alternative and in this proof of principle study, our aim was to systematically investigate whether blood is a viable surrogate for bone. We measured epigenome-wide DNA methylation at 850 K CpG sites in matched trabecular bone and peripheral blood collected from the same patients at the same time-point (n = 12 women; 66–85y), to investigate the between-tissue correspondence. What constituted a CpG site with corresponding methylation in both tissues was stringently defined. Only sites highly correlated (r2 > 0.74; FDR q-value

Published
2020

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