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Your search keyword '"Beck, Stephan"' showing total 10 results
Start Over Author "Beck, Stephan" Journal epigenetics
10 results on '"Beck, Stephan"'

1. “Epigenome-wide methylation profile of chronic kidney disease-derived arterial DNA uncovers novel pathways in disease-associated cardiovascular pathology.”

Author

Dritsoula, Athina, primary, Kislikova, Maria, additional, Oomatia, Amin, additional, Webster, Amy P., additional, Beck, Stephan, additional, Ponticos, Markella, additional, Lindsey, Ben, additional, Norman, Jill, additional, Wheeler, David C., additional, Oates, Thomas, additional, and Caplin, Ben, additional

Published
2020
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2. "Epigenome-wide methylation profile of chronic kidney disease-derived arterial DNA uncovers novel pathways in disease-associated cardiovascular pathology.".

Author

Dritsoula, Athina, Kislikova, Maria, Oomatia, Amin, Webster, Amy P., Beck, Stephan, Ponticos, Markella, Lindsey, Ben, Norman, Jill, Wheeler, David C., Oates, Thomas, and Caplin, Ben

Subjects
METHYLATION, KIDNEY diseases, CHRONIC kidney failure, PATHOLOGY, GENE expression
Abstract

Chronic kidney disease (CKD) related cardiovascular disease (CVD) is characterized by vascular remodelling with well-established structural and functional changes in the vascular wall such as arterial stiffness, matrix deposition, and calcification. These phenotypic changes resemble pathology seen in ageing, and are likely to be mediated by sustained alterations in gene expression, which may be caused by epigenetic changes such as tissue-specific DNA methylation. We aimed to investigate tissue specific changes in DNA methylation that occur in CKD-related CVD. Genome-wide DNA methylation changes were examined in bisulphite converted genomic DNA isolated from the vascular media of CKD and healthy arteries. Methylation-specific PCR was used to validate the array data, and the association between DNA methylation and gene and protein expression was examined. The DNA methylation age was compared to the chronological age in both cases and controls. Three hundred and nineteen differentially methylated regions (DMR) were identified spread across the genome. Pathway analysis revealed that DMRs associated with genes were involved in embryonic and vascular development, and signalling pathways such as TGFβ and FGF. Expression of top differentially methylated gene HOXA5 showed a significant negative correlation with DNA methylation. Interestingly, DNA methylation age and chronological age were highly correlated, but there was no evidence of accelerated age-related DNA methylation in the arteries of CKD patients. In conclusion, we demonstrated that differential DNA methylation in the arterial tissue of CKD patients represents a potential mediator of arterial pathology and may be used to uncover novel pathways in the genesis of CKD-associated complications. [ABSTRACT FROM AUTHOR]

Published
2021
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5. Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

Author

Wang, Yunzhang, primary, Karlsson, Robert, additional, Lampa, Erik, additional, Zhang, Qian, additional, Hedman, Åsa K., additional, Almgren, Malin, additional, Almqvist, Catarina, additional, McRae, Allan F., additional, Marioni, Riccardo E., additional, Ingelsson, Erik, additional, Visscher, Peter M., additional, Deary, Ian J., additional, Lind, Lars, additional, Morris, Tiffany, additional, Beck, Stephan, additional, Pedersen, Nancy L., additional, and Hägg, Sara, additional

Published
2018
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