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Your search keyword '"H. Korthals Altes"' showing total 2 results
Start Over Author "H. Korthals Altes" Journal epidemiology and infection
2 results on '"H. Korthals Altes"'

1. Association between season of vaccination and antibody levels against infectious diseases

Author

G. A. M. Berbers, Liesbeth Mollema, T. C. Abreu, H. Korthals Altes, Hendriek C. Boshuizen, and Epidemiology and Data Science

Subjects
0301 basic medicine, Male, Adolescent, Epidemiology, serology, Meningococcal Vaccines, Measles, Rubella, Antibodies, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Immunity, Seroepidemiologic Studies, vaccine, Medicine, Humans, Hepatitis B Vaccines, 030212 general & internal medicine, Vaccines, Combined, Seroconversion, Child, Diphtheria-Tetanus-Pertussis Vaccine, Immunization Schedule, Haemophilus Vaccines, Netherlands, Original Paper, Vaccines, Conjugate, business.industry, Tetanus, seasonality, Diphtheria, Vaccination, Infant, medicine.disease, Poliomyelitis, Poliovirus Vaccine, Inactivated, 030104 developmental biology, Infectious Diseases, Cross-Sectional Studies, Child, Preschool, Immunology, Childhood vaccination schedule, Communicable Disease Control, Female, Seasons, business, Measles-Mumps-Rubella Vaccine
Abstract

Vaccination has reduced the disease burden of vaccine-preventable diseases. However, the extent to which seasonal cycles of immunity could influence vaccine-induced immunity is not well understood. A national cross-sectional serosurveillance study performed in the Netherlands (Pienter-2) yielded data to investigate whether season of vaccination was associated with antibody responses induced by DT-IPV (diphtheria, tetanus and poliomyelitis), MMR (measles, mumps and rubella) and meningococcus C (MenC) vaccines in children. In total, 434 children met the inclusion criteria to study DT-IPV immunity, 811 for MMR and 311 for MenC. Differences in log(antibody levels) by season of vaccination were investigated with linear multivariable regression analyses. Seroconversion rates varied according to season of vaccination for rubella (90% of autumn-vaccinated childrenvs.99% of winter-vaccinated had concentrations above cut-off levels). Summer-vaccinated boys showed a slower decline of tetanus antibodies (6% per month), in comparison with winter-vaccinated boys. In conclusion, season of vaccination showed little association with immunological protection. However, a number of associations were seen with aP-value of about 0.03; and adding data from a just-completed nationwide serological study might add more power to the current study. Further immunological and longitudinal investigations could help understand the mechanisms of seasonal influence in vaccine-induced responses.

Published
2020
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2. Quantifying the impact of mass vaccination programmes on notified cases in the Netherlands.

Author

van Wijhe M, Tulen AD, Korthals Altes H, McDonald SA, de Melker HE, Postma MJ, and Wallinga J

Subjects
Child, Disease Notification statistics & numerical data, Female, Humans, Infant, Male, Netherlands epidemiology, Treatment Outcome, Diphtheria epidemiology, Diphtheria prevention & control, Disease Transmission, Infectious prevention & control, Immunization Programs, Mass Vaccination, Virus Diseases epidemiology, Virus Diseases prevention & control
Abstract

Vaccination programmes are considered a main contributor to the decline of infectious diseases over the 20th century. In recent years, the national vaccination coverage in the Netherlands has been declining, highlighting the need for continuous monitoring and evaluation of vaccination programmes. Our aim was to quantify the impact of long-standing vaccination programmes on notified cases in the Netherlands. We collected and digitised previously unavailable monthly case notifications of diphtheria, poliomyelitis, mumps and rubella in the Netherlands over the period 1919-2015. Poisson regression models accounting for seasonality, multi-year cycles, secular trends and auto-correlation were fit to pre-vaccination periods. Cases averted were calculated as the difference between observed and expected cases based on model projections. In the first 13 years of mass vaccinations, case notifications declined rapidly with 82.4% (95% credible interval (CI): 74.9-87.6) of notified cases of diphtheria averted, 92.9% (95% CI 85.0-97.2) cases of poliomyelitis, and 79.1% (95% CI 67.1-87.4) cases of mumps. Vaccination of 11-year-old girls against rubella averted 49.9% (95% CI 9.3-73.5) of cases, while universal vaccination averted 68.1% (95% CI 19.4-87.3) of cases. These findings show that vaccination programmes have contributed substantially to the reduction of infectious diseases in the Netherlands.

Published
2018
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