Search

Your search keyword '"De Grazia S."' showing total 8 results
Start Over Author "De Grazia S." Journal epidemiology and infection
8 results on '"De Grazia S."'

6. Waterborne Norovirus outbreak at a seaside resort likely originating from municipal water distribution system failure

Author

S. De Grazia, Floriana Bonura, C. Saglimbene, Giuseppa Purpari, S. Li Muli, Vincenzo Cappa, A. Pepe, I. Di Bartolo, Annalisa Guercio, M. Cuccia, Angelo Marino, Giovanni M. Giammanco, Noemi Urone, G. Mandolfo, Giammanco, G.M., Bonura, F., Urone, N., Purpari, G., Cuccia, M., Pepe, A., Li Muli, S., Cappa, V., Saglimbene, C., Mandolfo, G., Marino, A., Guercio, A., Di Bartolo, I., and De Grazia, S.

Subjects
Male, 0301 basic medicine, Settore MED/07 - Microbiologia E Microbiologia Clinica, Veterinary medicine, medicine.medical_specialty, waterborne, Adolescent, Epidemiology, 030106 microbiology, Sewage, medicine.disease_cause, Disease Outbreaks, 03 medical and health sciences, 0302 clinical medicine, Tap water, Waterborne Diseases, Genotype, medicine, Humans, 030212 general & internal medicine, Sicily, Feces, Caliciviridae Infections, Noroviru, Original Paper, business.industry, Drinking Water, Norovirus, Outbreak, Waterborne diseases, medicine.disease, Gastroenteritis, Infectious Diseases, Geography, Female, genotype GII.P2/GII.2, business, gastroenteritis outbreak
Abstract

In May 2016 a Norovirus (NoV) gastroenteritis outbreak involved a high school class visiting a seaside resort near Taormina (Mascali, Sicily). Twenty-four students and a teacher were affected and 17 of them showed symptoms on the second day of the journey, while the others got ill within the following 2 days. Symptoms included vomiting, diarrhoea and fever, and 12 students required hospitalisation. Stool samples tested positive for NoV genome by Real-Time polymerase chain reaction assay in all 25 symptomatic subjects. The GII.P2/GII.2 NoV genotype was linked to the outbreak by ORF1/ORF2 sequence analysis. The epidemiological features of the outbreak were consistent with food/waterborne followed by person-to-person and/or vomit transmission. Food consumed at a shared lunch on the first day of the trip was associated to illness and drinking un-bottled tap water was also considered as a risk factor. The analysis of water samples revealed the presence of bacterial indicators of faecal contamination in the water used in the resort as well as in other areas of the municipal water network, linking the NoV gastroenteritis outbreak to tap water pollution from sewage leakage. From a single water sample, an amplicon whose sequence corresponded to the capsid genotype recovered from patients could be obtained.

Published
2018

7. Nationwide surveillance study of human astrovirus infections in an Italian paediatric population

Author

P. Moschidou, Floriana Bonura, Maria Cristina Medici, Adriana Calderaro, Maria Chironna, Fabio Tummolo, S. De Grazia, Vito Martella, Giovanni M. Giammanco, DE GRAZIA, S., Martella, V., Chironna, M., Bonura, F., Tummolo, F., Calderaro, A., Moschidu, P., Giammanco, G., and Medici, M.

Subjects
Settore MED/07 - Microbiologia E Microbiologia Clinica, medicine.medical_specialty, Surveillance study, Genotype, Epidemiology, Short Report, Biology, Feces, Astroviridae Infections, Prevalence, medicine, Humans, Genetic variability, Genetic diversity, Infant, Human astrovirus, Virology, Northern italy, Astroviruses, epidemiology, gastroenteritis, virology (human), Infectious Diseases, Italy, Child, Preschool, Population Surveillance, Mamastrovirus, Paediatric population
Abstract

SUMMARYThe study investigated the genetic diversity of human astroviruses (HAstVs) detected in children hospitalized with gastroenteritis in Italy in 2008–2009. A total of 1321 faecal samples were collected in Parma (northern Italy), Bari (southern Italy), and Palermo (Sicily) and screened for the presence of HAstVs. RT–PCR amplification of a portion at the 5′-end of ORF2 allowed the detection of HAstVs in 3·95% of the patients. Four different genotypes (HAstV-1, HAstV-2, HAstV-4, HAstV-5) were found to be circulating during the study period, with HAstV-1 being the predominant type. Interestingly, a novel lineage, proposed as HAstV-2d, was found to have emerged in Parma in 2009. Investigating the genetic variability of HAstVs will be important for understanding the epidemiological trends and evolution of these viruses.

Published
2012

8. Nationwide surveillance study of human astrovirus infections in an Italian paediatric population.

Author

DE Grazia S, Martella V, Chironna M, Bonura F, Tummolo F, Calderaro A, Moschidou P, Giammanco GM, and Medici MC

Subjects
Child, Preschool, Feces virology, Genotype, Humans, Infant, Italy epidemiology, Mamastrovirus isolation & purification, Prevalence, Astroviridae Infections epidemiology, Astroviridae Infections virology, Mamastrovirus genetics, Population Surveillance
Abstract

The study investigated the genetic diversity of human astroviruses (HAstVs) detected in children hospitalized with gastroenteritis in Italy in 2008-2009. A total of 1321 faecal samples were collected in Parma (northern Italy), Bari (southern Italy), and Palermo (Sicily) and screened for the presence of HAstVs. RT-PCR amplification of a portion at the 5'-end of ORF2 allowed the detection of HAstVs in 3·95% of the patients. Four different genotypes (HAstV-1, HAstV-2, HAstV-4, HAstV-5) were found to be circulating during the study period, with HAstV-1 being the predominant type. Interestingly, a novel lineage, proposed as HAstV-2d, was found to have emerged in Parma in 2009. Investigating the genetic variability of HAstVs will be important for understanding the epidemiological trends and evolution of these viruses.

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results