1. Interpregnancy Interval and Risk of Autistic Disorder
- Author
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Mady Hornig, Camilla Stoltenberg, Per Magnus, Kari Kveim Lie, Michaeline Bresnahan, Roy Miodini Nilsen, Synnve Schjølberg, W. Ian Lipkin, Ted Reichborn-Kjennerud, Nina Gunnes, Anne-Siri Øyen, Pål Surén, and Ezra Susser
- Subjects
Male ,Risk ,Time Factors ,Norway ,Epidemiology ,business.industry ,Singleton ,Odds ratio ,Confidence interval ,Interval (music) ,Birth Intervals ,Increased risk ,Humans ,Medicine ,Female ,Registry data ,Registries ,Autistic Disorder ,Sibling ,Child ,business ,Demography - Abstract
BACKGROUND A recent California study reported increased risk of autistic disorder in children conceived within a year after the birth of a sibling. METHODS We assessed the association between interpregnancy interval and risk of autistic disorder using nationwide registry data on pairs of singleton full siblings born in Norway. We defined interpregnancy interval as the time from birth of the first-born child to conception of the second-born child in a sibship. The outcome of interest was autistic disorder in the second-born child. Analyses were restricted to sibships in which the second-born child was born in 1990-2004. Odds ratios (ORs) were estimated by fitting ordinary logistic models and logistic generalized additive models. RESULTS The study sample included 223,476 singleton full-sibling pairs. In sibships with interpregnancy intervals
- Published
- 2013