1. Risk stratification of cardiovascular and heart failure hospitalizations using integrated device diagnostics in patients with a cardiac resynchronization therapy defibrillator
- Author
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Giuseppe Boriani, Lorenza Mangoni di S. Stefano, Renato Pietro Ricci, Haran Burri, Federico Segura Villalobos, Antoine Da Costa, Nicolas Clementy, Gabriele Boscolo, Stefano Favale, Vinod Sharma, and Aurelio Quesada
- Subjects
Male ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,law.invention ,Cardiac Resynchronization Therapy ,0302 clinical medicine ,Randomized controlled trial ,law ,030212 general & internal medicine ,ddc:616 ,Cardiac resynchronization therapy ,virus diseases ,Middle Aged ,Telemedicine ,Defibrillators, Implantable ,Europe ,Hospitalization ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,Algorithms ,Integrated diagnostics ,medicine.medical_specialty ,Heart failure ,Risk Assessment ,03 medical and health sciences ,Physiology (medical) ,Internal medicine ,Post-hoc analysis ,medicine ,Humans ,Cardiac Resynchronization Therapy Devices ,Risk stratification ,Aged ,Monitoring, Physiologic ,Heart Failure ,Remote monitoring ,Symptoms ,business.industry ,Reproducibility of Results ,medicine.disease ,Triage ,Clinical trial ,Relative risk ,Remote Sensing Technology ,business - Abstract
Aims Cardiac resynchronization therapy defibrillators (CRT-D) are able to monitor various parameters that may be combined by an automatic algorithm to provide a heart failure risk status (HFRS). We sought to validate the HFRS for stratifying patient risk, evaluate its association with heart failure (HF) symptoms, and investigate its utility for triage of automatic alerts. Methods and results Data from 722 patients included in the MORE-CARE trial were analysed in a post hoc analysis. A high HFRS was associated with a significantly increased risk of admission over the next 30 days with a relative risk for cardiovascular hospitalization (CVH) of 4.5 (95% CI: 3.1-6.6, P
- Published
- 2017
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