1. Chromosome aberrations as a biological dosimeter in Thorotrast patients: Dosimetric problems
- Author
-
H. Muth, W. Kemmer, and A. Steinsträsser
- Subjects
Radiation Dosage ,Biochemistry ,Chromosome aberration ,Dicentric chromosome ,chemistry.chemical_compound ,Expired air ,MicroDose ,Bone Marrow ,Humans ,Lymphocytes ,Thorotrast ,General Environmental Science ,Chromosome Aberrations ,Dosimeter ,business.industry ,Chemistry ,Chromosome ,Dose-Response Relationship, Radiation ,Radiography ,Liver ,Absorbed dose ,Thorium Dioxide ,Lymph Nodes ,Nuclear medicine ,business ,Relative Biological Effectiveness ,Spleen - Abstract
The results of chromosome aberration analyses in 68 Thorotrast patients are discussed. In all patients dicentric chromosome aberrations were found but the chromosome aberration rate neither corresponds with the calculated whole body activity or the estimated absorbed dose in the organs of the RHS nor with the “radium-224-equivalent value” calculated from the radon-220 activity measured in the expired air. From X-ray examinations and histologic studies of lymph nodes the conclusion is drawn that the “microdose” absorbed from one lymphocyte is not in relation to the mean absorbed RHS dose, calculated from biophysical measurements.
- Published
- 1979