1. Effects of environmental cadmium and lead exposure on adults neighboring a discharge: Evidences of adverse health effects
- Author
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Dorothée Dewaele, Saâd Bouhsina, Amadou Diouf, Cheikh Diop, Pirouz Shirali, Anta Tall-Dia, Mathilde Cabral, Dominique Courcot, Aminata Toure, Fabrice Cazier, Anthony Verdin, Guillaume Garçon, and Mamadou Fall
- Subjects
Adult ,Male ,medicine.medical_specialty ,Antioxidant ,Adolescent ,Health, Toxicology and Mutagenesis ,Urinary system ,medicine.medical_treatment ,Population ,Urine ,Kidney ,Toxicology ,medicine.disease_cause ,Antioxidants ,Nephrotoxicity ,Lipid peroxidation ,Young Adult ,chemistry.chemical_compound ,Internal medicine ,medicine ,Humans ,education ,Aged ,education.field_of_study ,Chemistry ,Environmental Exposure ,General Medicine ,Glutathione ,Middle Aged ,Pollution ,Senegal ,Oxidative Stress ,Waste Disposal Facilities ,Endocrinology ,Lead ,Female ,Lipid Peroxidation ,Reactive Oxygen Species ,Biomarkers ,Oxidative stress ,Cadmium - Abstract
The purpose of the study was to determine Pb and Cd concentrations in humans and to assess the effect of co-exposure to these metals on biomarkers of oxidative stress and nephrotoxicity. Blood and urine levels of Pb and Cd, oxidative stress and urinary renal biomarkers were measured in 77 subjects neighboring a discharge and 52 in the control site. Exposed subjects showed significantly higher levels of lead and cadmium in blood and urine than the controls. Excessive production of reactive oxygen species induced by these metals in exposed subjects conducted to a decrease in antioxidant defense system (GPx, Selenium, GSH) and an increase in lipid peroxidation (MDA). Moreover, changes in markers of nephrotoxicity (high urinary concentrations of total protein, RBP and CC16, as well as GSTα and LDH increased activities) suggested the occurrence of discrete and early signs of impaired renal function for the discharge neighboring population.
- Published
- 2015
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