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Extended Producer Responsibility (EPR) principles have emerged as the template for e-waste policies, centered on establishing regulated collection and recycling channels. Originating in the global North, these policies are increasingly adopted in the global South where e-waste is primarily 'managed' by the informal sector, centered in spatially defined hubs. These formal systems fail to achieve collection quotas, while further marginalizing informal recyclers by delegitimizing their access to e-waste. We suggest an alternative hub-centered approach to e-waste reform based on eight years of research and advocacy within the Israel-West Bank e-waste system. We offer several converging rationales for centralizing hubs in e-waste policies and a case study demonstrating an integrated hub-driven package of business, enforcement, and cleanup measures. While the unique complexities of the Israeli-Palestinian case offer an exceptional window into the dynamics of a hub-driven approach, similar packages might shape e-waste policy reform throughout the global South. [ABSTRACT FROM AUTHOR]