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Start Over Author "Hanqiao LIU" Journal environment international
2 results on '"Hanqiao LIU"'

1. Transcriptomic changes in the nasal epithelium associated with diesel engine exhaust exposure

Author

E. Drizik, S. Corbett, Y. Zheng, R. Vermeulen, Y. Dai, W. Hu, D. Ren, H. Duan, Y. Niu, J. Xu, W. Fu, K. Meliefste, B. Zhou, Xiaohui Zhang, J. Yang, Bryan Bassig, Hanqiao Liu, M. Ye, Gang Liu, X. Jia, T. Meng, P. Bin, J. Zhang, D. Silverman, A. Spira, N. Rothman, M.E. Lenburg, and Q. Lan

Subjects
Environmental sciences, GE1-350
Abstract

Background: Diesel engine exhaust (DEE) exposure causes lung cancer, but the molecular mechanisms by which this occurs are not well understood. Objectives: To assess transcriptomic alterations in nasal epithelium of DEE-exposed factory workers to better understand the cellular and molecular effects of DEE. Methods: Nasal epithelial brushings were obtained from 41 diesel engine factory workers exposed to relatively high levels of DEE (17.2–105.4 μg/m3), and 38 unexposed workers from factories without DEE exposure. mRNA was profiled for gene expression using Affymetrix microarrays. Linear modeling was used to identify differentially expressed genes associated with DEE exposure and interaction effects with current smoking status. Pathway enrichment among differentially expressed genes was assessed using EnrichR. Gene Set Enrichment Analysis (GSEA) was used to compare gene expression patterns between datasets. Results: 225 genes had expression associated with DEE exposure after adjusting for smoking status (FDR q

Published
2020
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2. Transcriptomic changes in the nasal epithelium associated with diesel engine exhaust exposure

Author

Marc E. Lenburg, Jufang Yang, Roel Vermeulen, Sean Corbett, Hanqiao Liu, D. Silverman, Tao Meng, Kees Meliefste, Xiaowei Jia, Ping Bin, Yan Dai, Junfeng Zhang, Eduard Drizik, Bryan A. Bassig, Jun Xu, Gang Liu, Wei Fu, B. Zhou, Avrum Spira, Yong Niu, Wei Hu, Dianzhi Ren, Meng Ye, Xiaohui Zhang, Huawei Duan, Qing Lan, Yuxin Zheng, and Nathaniel Rothman

Subjects
MAPK/ERK pathway, 010504 meteorology & atmospheric sciences, Microarray, 010501 environmental sciences, Biology, medicine.disease_cause, 01 natural sciences, Article, Andrology, Transcriptome, Gene expression, medicine, Humans, Gene, lcsh:Environmental sciences, 0105 earth and related environmental sciences, General Environmental Science, Vehicle Emissions, lcsh:GE1-350, Messenger RNA, Diesel engine exhaust, Cell cycle, Occupational exposure, Nasal Mucosa, Leukocytes, Mononuclear, Lung cancer, Oxidative stress
Abstract

Background: Diesel engine exhaust (DEE) exposure causes lung cancer, but the molecular mechanisms by which this occurs are not well understood. Objectives: To assess transcriptomic alterations in nasal epithelium of DEE-exposed factory workers to better understand the cellular and molecular effects of DEE. Methods: Nasal epithelial brushings were obtained from 41 diesel engine factory workers exposed to relatively high levels of DEE (17.2–105.4 μg/m3), and 38 unexposed workers from factories without DEE exposure. mRNA was profiled for gene expression using Affymetrix microarrays. Linear modeling was used to identify differentially expressed genes associated with DEE exposure and interaction effects with current smoking status. Pathway enrichment among differentially expressed genes was assessed using EnrichR. Gene Set Enrichment Analysis (GSEA) was used to compare gene expression patterns between datasets. Results: 225 genes had expression associated with DEE exposure after adjusting for smoking status (FDR q

Published
2020

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