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Your search keyword '"Debrauwer, Laurent"' showing total 7 results
Start Over Author "Debrauwer, Laurent" Journal environment international
7 results on '"Debrauwer, Laurent"'

1. Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment

Author

Tkalec, Žiga, Antignac, Jean-Philippe, Bandow, Nicole, Béen, Frederic M., Belova, Lidia, Bessems, Jos, Le Bizec, Bruno, Brack, Werner, Cano-Sancho, German, Chaker, Jade, Covaci, Adrian, Creusot, Nicolas, David, Arthur, Debrauwer, Laurent, Dervilly, Gaud, Duca, Radu Corneliu, Fessard, Valérie, Grimalt, Joan O., Guerin, Thierry, Habchi, Baninia, Hecht, Helge, Hollender, Juliane, Jamin, Emilien L., Klánová, Jana, Kosjek, Tina, Krauss, Martin, Lamoree, Marja, Lavison-Bompard, Gwenaelle, Meijer, Jeroen, Moeller, Ruth, Mol, Hans, Mompelat, Sophie, Van Nieuwenhuyse, An, Oberacher, Herbert, Parinet, Julien, Van Poucke, Christof, Roškar, Robert, Togola, Anne, Trontelj, Jurij, and Price, Elliott J.

Published
2024
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2. Perinatal exposure to a dietary pesticide cocktail does not increase susceptibility to high-fat diet-induced metabolic perturbations at adulthood but modifies urinary and fecal metabolic fingerprints in C57Bl6/J mice

Author

Smith, Lorraine, Klément, Wendy, Dopavogui, Léonie, de Bock, Frédéric, Lasserre, Frédéric, Barretto, Sharon, Lukowicz, Céline, Fougerat, Anne, Polizzi, Arnaud, Schaal, Benoist, Patris, Bruno, Denis, Colette, Feuillet, Guylène, Canlet, Cécile, Jamin, Emilien L, Debrauwer, Laurent, Mselli-Lakhal, Laila, Loiseau, Nicolas, Guillou, Hervé, Marchi, Nicola, Ellero-Simatos, Sandrine, and Gamet-Payrastre, Laurence

Published
2020
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3. A large scale multi-laboratory suspect screening of pesticide metabolites in human biomonitoring: From tentative annotations to verified occurrences

Author

Huber, Carolin, primary, Nijssen, Rosalie, additional, Mol, Hans, additional, Philippe Antignac, Jean, additional, Krauss, Martin, additional, Brack, Werner, additional, Wagner, Kevin, additional, Debrauwer, Laurent, additional, Maria Vitale, Chiara, additional, James Price, Elliott, additional, Klanova, Jana, additional, Garlito Molina, Borja, additional, Leon, Nuria, additional, Pardo, Olga, additional, Fernández, Sandra F., additional, Szigeti, Tamás, additional, Középesy, Szilvia, additional, Šulc, Libor, additional, Čupr, Pavel, additional, Mārtiņsone, Inese, additional, Akülova, Läsma, additional, Ottenbros, Ilse, additional, Vermeulen, Roel, additional, Vlaanderen, Jelle, additional, Luijten, Mirjam, additional, and Lommen, Arjen, additional

Published
2022
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4. An annotation database for chemicals of emerging concern in exposome research

Author

Meijer, Jeroen, primary, Lamoree, Marja, additional, Hamers, Timo, additional, Antignac, Jean-Philippe, additional, Hutinet, Sébastien, additional, Debrauwer, Laurent, additional, Covaci, Adrian, additional, Huber, Carolin, additional, Krauss, Martin, additional, Walker, Douglas I., additional, Schymanski, Emma L., additional, Vermeulen, Roel, additional, and Vlaanderen, Jelle, additional

Published
2021
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5. Suspect and non-targeted screening of chemicals of emerging concern for human biomonitoring, environmental health studies and support to risk assessment: From promises to challenges and harmonisation issues

Author

Pourchet, Mariane, primary, Debrauwer, Laurent, additional, Klanova, Jana, additional, Price, Elliott J., additional, Covaci, Adrian, additional, Caballero-Casero, Noelia, additional, Oberacher, Herbert, additional, Lamoree, Marja, additional, Damont, Annelaure, additional, Fenaille, François, additional, Vlaanderen, Jelle, additional, Meijer, Jeroen, additional, Krauss, Martin, additional, Sarigiannis, Denis, additional, Barouki, Robert, additional, Le Bizec, Bruno, additional, and Antignac, Jean-Philippe, additional

Published
2020
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7. Disposition and metabolic profiling of [14C]-Decabromodiphenyl ether in pregnant Wistar rats

Author

Riu, Anne, Cravedi, Jean-Pierre, Debrauwer, Laurent, Garcia, Aurélie, Canlet, Cécile, Jouanin, Isabelle, and Zalko, Daniel

Subjects
*METABOLITES, *PHYSICAL & theoretical chemistry, *BIOLOGICAL products, *BILIARY tract, *ORGANIC compounds, *ENDOCRINE glands, *FIREPROOFING agents
Abstract

Abstract: Fully brominated diphenyl ether, decabromodiphenyl ether (DBDE), is one of the most widely used brominated flame retardants worldwide. Little data is available about the metabolic fate of DBDE in animal models and nothing at all about the extent of foetal exposure. In this work, pregnant Wistar rats were force-fed with 99.8% pure [14C]-DBDE over 96 h at a late stage of gestation (days 16 to 19). More than 19% of the administered dose was recovered in tissues and carcasses, demonstrating efficient absorption of DBDE despite its high molecular weight and low solubility. The highest concentrations of DBDE residues were found in endocrine glands (adrenals, ovaries) and in the liver, with lower values recorded for fat. In all tissue extracts, most of the radioactivity was associated with unchanged DBDE. The use of high-grade purity [14C]-DBDE allowed quantification of several metabolites present both in maternal tissues and in foetuses. These biotransformation products accounted for 9–27% of the extractable radioactivity in tissues and 14% of that in foetuses. Three nona-BDEs and one octa-BDE were identified by LC-APPI/MS. The unequivocal characterisation of a hydroxylated octa-BDE isolated from liver was confirmed by NMR. In rat, the main metabolic pathways of DBDE are debromination and oxidation. DBDE, and very likely most of its metabolites, are able to cross the placental barrier in rat. Metabolic profiles, obtained in vivo for the first time, demonstrated the presence of DBDE and major biotransformation products in endocrine glands as well as in foetuses. The biological activity of these metabolites still needs to be assessed in order to better understand the potential toxicity of DBDE. [Copyright &y& Elsevier]

Published
2008
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