1. Prenatal exposure to selenium, mercury, and manganese during pregnancy and allergic diseases in early childhood: The Japan Environment and Children's study.
- Author
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Miyazaki, Junji, Ikehara, Satoyo, Tanigawa, Kanami, Kimura, Takashi, Ueda, Kimiko, Ozono, Keiichi, Kimura, Tadashi, Kobayashi, Yayoi, Yamazaki, Shin, Kamijima, Michihiro, Sobue, Tomotaka, and Iso, Hiroyasu
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ALLERGIES , *PRENATAL exposure , *JUVENILE diseases , *METALS , *FOOD allergy , *SELENIUM , *TOBACCO smoke - Abstract
[Display omitted] • Prenatal selenium exposure was inversely associated with allergic disease risks. • The inverse associations were more evident for lower mercury exposure. • Selenium-rich foods but not predatory fish are recommended for pregnant women. • Selenium exposure may be beneficial for allergic disease risk reduction. Prenatal exposure to metallic elements may adversely affect early childhood health. However, more evidence is needed as population-based cohort studies are currently limited. We aimed to examine the associations between prenatal metallic (mercury, selenium, and manganese) exposure and the risk of allergic diseases in early childhood until three years of age. The data from 94,794 mother-infant pairs, who participated in the Japan Environment and Children's study, were used in this study. Prenatal metallic element exposure was measured in maternal blood collected during mid-pregnancy. The incidence of atopic dermatitis, food allergies, asthma, and allergic rhinitis during the first three years of life was prospectively investigated using self-reports of physician-diagnosed allergies. A multivariable modified Poisson regression model was used to estimate the cumulative incidence ratio and their 95% confidence intervals of allergic diseases associated with prenatal exposure to mercury, selenium, and manganese. We further evaluated the interaction between mercury and selenium exposures in this association. We confirmed 26,238 cases of childhood allergic diseases: atopic dermatitis, food allergies, asthma, and allergic rhinitis in 9,715 (10.3%), 10,897 (11.5%), and 9,857 (10.4%), 4,630 (4.9%), respectively. No association was found between prenatal mercury or manganese exposure and the risk of allergic diseases. Prenatal selenium exposure was inversely associated with atopic dermatitis, food allergies, allergic rhinitis, and any allergic diseases, but not with asthma. These inverse associations were more pronounced for lower mercury exposures than for higher exposures. Our findings suggest that prenatal exposure to selenium may be beneficial for reducing the risk of atopic dermatitis, food allergies, allergic rhinitis, and any allergic diseases in early childhood, especially with lower prenatal mercury exposure. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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