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A morphological and biochemical study of calcifying tendinitis in twy mouse was carried out. Calcification of the aponeurosis plantaris was first observed at the 7th week of age. Thereafter multinucleated giant cells and histiocytes were seen around the calcium deposits. Infiltration of polymorphonuclear leukocytes followed. These inflammatory cell reaction confined to the tendon. Then, proliferation of capillaries and fibroblasts was observed, and lacunar formation around the calcium deposits was sometimes observed. In later stage, inflammatory cell infiltration subsided, and fibrous scar and calcium deposits were recognized in the tendon. Deposition of hydroxyapatite was confirmed in the tendon by X-ray powder analysis.These changes resemble those of man, and calcifying tendinitis in twy mouse is thought to be a valuable model of the corresponding disease in man.