1. Effect of juzentaihoto on phagocytes
- Author
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Yasuhiro Komatsu, Eikichi Hosoya, Masaki Aburada, Norito Takemoto, Hirofumi Maruyama, and Hideki Kawamura
- Subjects
business.industry ,Kampo ,Phagocytosis ,In vitro ,Juzentaihoto ,Andrology ,Basal (phylogenetics) ,medicine.anatomical_structure ,Oral administration ,PEG ratio ,Immunology ,Medicine ,Bone marrow ,business - Abstract
The effect of one of Kampo prescriptions, Tsumura Juzentaihoto (TJ-48), on phagocytes was investigated in BALB/c mice.The oral administration of TJ-48 for 3 to 5 days resulted in the enhanced phagocytic activity of peritoneal exudate cells (PEC) and bone marrow cells (BMC) and the maximum increase was observed at 2 g/kg/day of TJ-48. The enhanced phagocytosis was maintained for 5 days after the withdrawal of TJ-48 and returned to the basal level on day 7. A large increase of chemiluminescence was obtained in PEG from mice given TJ-48 orally for 7 days. Moreover, TJ-48 showed the direct activatingeffect on the phagocytosis of PEC and BMC in in vitro assay.
- Published
- 1988