1. Microflow system promotes acetaminophen crystal nucleation
- Author
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Hiroshi Yoshikawa, Kazufumi Takano, Akari Nishigaki, Mihoko Maruyama, Masayuki Imanishi, Munenori Numata, Shun-ichi Tanaka, Masashi Yoshimura, Chisako Kanzaki, and Yusuke Mori
- Subjects
0106 biological sciences ,Environmental Engineering ,Materials science ,liquid–liquid interface ,Nucleation ,Mixing (process engineering) ,polymorph control ,Bioengineering ,anti‐solvent method ,01 natural sciences ,law.invention ,Physics::Fluid Dynamics ,Crystal ,03 medical and health sciences ,laminar flow ,law ,010608 biotechnology ,Metastability ,Crystallization ,Research Articles ,030304 developmental biology ,0303 health sciences ,Microchannel ,metastable form ,Laminar flow ,Volumetric flow rate ,Condensed Matter::Soft Condensed Matter ,Chemical engineering ,Research Article ,Biotechnology - Abstract
It is known that interfaces have various impacts on crystallization from a solution. Here, we describe crystallization of acetaminophen using a microflow channel, in which two liquids meet and form a liquid–liquid interface due to laminar flow, resulting in uniform mixing of solvents on the molecular scale. In the anti‐solvent method, the microflow mixing promoted the crystallization more than bulk mixing. Furthermore, increased flow rate encouraged crystal formation, and a metastable form appeared under a certain flow condition. This means that interface management by the microchannel could be a beneficial tool for crystallization and polymorph control.
- Published
- 2020
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