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Decoupling the physical world and providing standardized service interfaces is still challenging when developing Location Based Services (LBS). This lack also hinders the possibility of developing Intelligent services on top of LBS architectures. In this paper, we propose a multi-layer Digital Twin-based architecture that aims to enable the development of machine learning-based Intelligent LBS (I-LBS) that are able to adapt, evolve, and perform Continual Learning (CL). The platform uses Digital Twins to ensure physical abstraction and provide cyber–physical knowledge to the I-LBSs, which is defined as an execution graph of operation modules. Finally, we simulated a use-case for this platform in the complex scenario of Healthcare organization and management where the I-LBS classifies allowed/not allowed trajectories of users inside a real-existing hospital scenario depending on their role in the organization. The use case is implemented as a Deep Learning-based reconstruction task of high-resolution trajectories processed by the DT architecture that also deploys the I-LBS. The platform is evaluated in terms of physical complexity and computational time on the DT side and on both a traditional machine learning setting and a replay-based CL one for the intelligence side to demonstrate the flexibility and adaptability features introduced by the components for dynamic or unseen scenarios. [ABSTRACT FROM AUTHOR]