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Objective: Verifying satisfaction and fatigue due to compassion and its associated factors in nurses of the Basic Health Unit. Method: A descriptive and cross-sectional research developed with 101 nurses from 40 Basic Health Units in a municipality of Parana. Data were collected between November 2019 and February 2020 through a questionnaire of sociodemographic characterization, occupational and life habits and the Professional Quality of Life Scale that assesses Satisfaction and Fatigue by Compassion. The associated factors were obtained by logistic regression models. Results: Having a good interpersonal relationship decreased the chances of low satisfaction by compassion (p=0.025) and burnout (p=0.049). Being recognized at work had a significantly lower probability of low compassion satisfaction (p=0.040). Conclusion: Good interpersonal relationships were associated with compassion satisfaction and burnout. Feeling recognized for the work done was also associated with satisfaction for compassion. Most nurses, even with high levels of satisfaction due to compassion, feel tired, which leads to reinforce the need for greater attention to the work developed by nurses in the Basic Health Unit by managers. [ABSTRACT FROM AUTHOR]