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Abstract: Thermal comfort plays a major factor in building infrastructure sector. It has a big impact on building interior temperature as well as on energy balance and environment. In the current paper the influence of thermal isolation, building orientation and thermal inertia of building envelop on interior ambient temperatures have been studied. To meet our objective, a methodological procedure has been followed. It consists of elaboration of computing program written in MATLAB code to simulate the proposed mathematical model. The main objective of the proposed mathematical proposed model is to compute different delivered temperatures under real climatic and environment conditions. Confrontation of the results found through simulation with those found experimentally shows a clear consistence. Thus the theoretical model is experimentally validated. It can be concluded that: The most effective measure to achieve a better results is thermal insulation. The orientation of thermally isolated building doesn’t have a considerable impact on interior temperature. Thermal inertia of buildings may thus generate thermal comfort. It was revealed that an adequate use of stone thermal inertia is essential to achieve a better building thermal comfort. [Copyright &y& Elsevier]