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Abstract: In this paper the comparison between the performance of a cross flow heat exchanger in wet and dry operation for air handling process has been investigated. In addition, a case study of application of the component to perform indirect evaporative cooling in a AHU was studied with the software TRNSYS.Using experimental data and an appropriate analytical method, energy saving performances of the system has been evaluated through the entire cooling season for a typical Mediterranean site. Results show that high energy saving potential can be obtained if the component is operated in wet operation in term of reduction of electricity consumption. [Copyright &y& Elsevier]