These variables include the type of nanoparticle additives integrated into the fuel blend and the operational engine speed. The focus is on two specific oxygenated additives, methanol and isobutanol, in conjunction with Methyl Tertiary-Butyl Ether (MTBE) and two metal oxide nanoparticles, namely magnesium oxide and titanium oxide. The experimental framework entails testing these new fuel blends in a controlled environment, utilizing a four-stroke engine linked to a dynamometer and a speed analyzer. The tests are conducted at rotational speeds of 750 and 1250 rpm. The comprehensive data collected encompass a range of parameters, including engine power and torque, as well as the emissions of carbon dioxide (CO 2), nitrogen oxides (NOx), unburned hydrocarbons (HC), and carbon monoxide (CO). The study meticulously analyzes data to build a robust model, significantly enhancing engine performance while substantially lowering emissions. It finds that adding specific additives to gasoline notably reduces carbon monoxide and hydrocarbons. Testing gasoline with methanol, MTBE, and titanium oxide at 750 RPM showed a notable shift in emissions: nitrogen oxide increased by 40.5%, while hydrocarbons, CO, and CO2 saw reductions of 17.5%, and from 2.4% to 7.8%–1.197% and 7.661%, respectively, underlining the need for careful fuel composition management for environmental benefits. • Novel and effective nano particles additives (MgO and TiO 2) are introduced to add gasoline. • Improving the Performance of Gasoline Fuels by Adding Methanol, Isobutanol and MTBE. • Taguchi experiment design is performed to evaluate effects of 6 parameters on blended fuels. • Modeling and optimization of the response including emissions and engine performance are implemented. • Verification and accuracy analysis are performed for models. [ABSTRACT FROM AUTHOR]