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The article discusses a study on the treatment of residual colorectal neoplasia using endoscopic submucosal dissection (ESD) or the full-thickness resection device (FTRD). The authors express concerns about the study, particularly regarding the lack of information on the patients' original disease and the effectiveness of the FTRD system for larger lesions. They also question whether postoperative infection rates and hospitalization duration should have been included as adverse events. The authors note that the choice between ESD and FTRD was at the physician's discretion, which may have introduced selection bias. Despite these limitations, both ESD and FTRD are considered viable treatment options for residual colorectal neoplasia. [Extracted from the article]

The article discusses a study on the efficacy and safety of endoscopic papillectomy for ampullary lesions in patients with familial adenomatous polyposis (FAP) compared to sporadic lesions. The authors raise some questions about the research, including the significant difference in the R0 resection rate between the two groups and the appropriateness of considering radiofrequency ablation and argon plasma coagulation as endoscopic remedies. They also suggest that analyzing the recurrence rate of all patients would be more reasonable and necessary. Despite these limitations, the authors conclude that endoscopic papillectomy remains a useful method for ampullary lesions in patients with FAP. [Extracted from the article]

This letter responds to an article discussing the effectiveness and safety of the no-touch endoscopic full-thickness resection (NT-EFTR) technique for gastric gastrointestinal stromal tumors (GISTs). The authors raise several questions about the study, including concerns about the retrieval of larger tumors intact, the lack of information about tumor origin, and the smaller diameter of the gastric wall defect compared to the tumor diameter. Despite these concerns, the authors acknowledge that NT-EFTR remains a useful method for gastric GISTs, particularly those with extraluminal growth. It is important to note that this letter represents the opinions of the authors and not necessarily the editor or publisher. [Extracted from the article]

Background and study aims Successful closure of the postoperative mucosal defect is crucial for endoscopic treatment. The purse-string suture strategy via a double-channel endoscope has been recommended as being both safe and feasible for large gastrointestinal mucosal defects. However, for colonic treatment, use of a single-channel colonoscope is more popular because of its longer length and greater flexibility. A novel pre-detached endoloop system was therefore developed for endoscopic purse-string suture closure via a single-channel endoscope. This study evaluated its feasibility and efficacy, especially for right colonic mucosal defects. Patients and methods A total of 18 patients with colonic defects post-endoscopic submucosal dissection (ESD) were treated using the single-channel endoscope method. Results All mucosal defects were successfully closed using the novel closure technique. No severe complications, such as massive intraoperative bleeding, delayed bleeding, peritonitis, or perforation, were recorded. All patients recovered well after ESD and left the hospital within 7 days. Conclusions This novel pre-detached endoloop strategy via a single-channel endoscope was safe and feasible for the closure of colonic mucosal defects using an endoscopic purse-string suture. [ABSTRACT FROM AUTHOR]

Competing Interests: The authors declare that they have no conflict of interest.