10 results on '"Shu Hoteya"'
Search Results
2. Outcomes of endoscopic resection for superficial duodenal tumors: 10 years' experience in 18 Japanese high volume centers
- Author
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Shu Hoteya, Yasushi Yamasaki, Yoji Takeuchi, Tsuneo Oyama, Yuko Hara, Tomoaki Tashima, Motohiko Kato, Nobutsugu Abe, Kengo Takimoto, Naohisa Yahagi, Hisashi Doyama, Osamu Dohi, Koichi Kurahara, Hiroya Ueyama, Naomi Kakushima, Ken Ohata, Atsushi Nakayama, Ichiro Oda, Hironori Yamamoto, Shoichi Yoshimizu, and Satoru Nonaka
- Subjects
medicine.medical_specialty ,Endoscopic Mucosal Resection ,business.industry ,Perforation (oil well) ,Gastroenterology ,En bloc resection ,Endoscopic mucosal resection ,Endoscopic submucosal dissection ,Surgery ,Treatment Outcome ,Multicenter study ,Japan ,Duodenal Neoplasms ,medicine ,Humans ,Endoscopic resection ,Cold polypectomy ,Intestinal Mucosa ,Neoplasm Recurrence, Local ,business ,Adverse effect ,Retrospective Studies - Abstract
Background Data on endoscopic resection (ER) for superficial duodenal epithelial tumors (SDETs) are insufficient owing to their rarity. There are two main ER techniques for SDETs: endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD). In addition, modified EMR techniques, such as underwater EMR (UEMR) and cold polypectomy, are becoming popular. We conducted a large-scale retrospective multicenter study to clarify the detailed outcomes of duodenal ER. Methods Patients with SDETs who underwent ER at 18 institutions from January 2008 to December 2018 were included. The rates of en bloc resection and delayed adverse events (AEs; defined as delayed bleeding or perforation) were analyzed. Local recurrence was analyzed using the Kaplan–Meier method. Results In total, 3107 patients (including 1017 undergoing ESD) were included. En bloc resection rates were 79.1 %, 78.6 %, 86.8 %, and 94.8 %, and delayed AE rates were 0.5 %, 2.2 %, 2.8 %, and 6.8 % for cold polypectomy, UEMR, EMR and ESD, respectively. The delayed AE rate was significantly higher in the ESD group than in non-ESD groups for lesions 20 mm (6.1 % vs. 7.1 %; P = 0.64). The local recurrence rate was significantly lower in the ESD group than in the non-ESD groups (P 30 mm, the cumulative local recurrence rate at 2 years was 22.6 % in the non-ESD groups compared with only 1.6 % in the ESD group (P Conclusions ER outcomes for SDETs were generally acceptable. ESD by highly experienced endoscopists might be an option for very large SDETs.
- Published
- 2021
3. A new device for simultaneous manipulation of an endoscope and a treatment device during procedures: an ex vivo animal study
- Author
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Akira Matsui, Daisuke Kikuchi, Yasutaka Kuribayashi, Toshiro Iizuka, Ryusuke Kimura, Satoshi Yamashita, Tsukasa Furuhata, Shu Hoteya, Toshifumi Mitani, Kosuke Nomura, Mitsuru Kaise, Osamu Ogawa, Akihiro Yamada, and Naohisa Yahagi
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medicine.medical_specialty ,Endoscope ,Swine ,business.industry ,Dissection ,Controller (computing) ,Operative Time ,Forceps ,Gastroenterology ,Equipment Design ,Dissection (medical) ,Thumb ,medicine.disease ,Endoscopy, Gastrointestinal ,Surgery ,body regions ,Catheter ,medicine.anatomical_structure ,Gastric Mucosa ,Animals ,Medicine ,New device ,Animal study ,business - Abstract
Background and study aims: Endoscopists must maneuver both endoscope and treatment device during procedures, requiring them to release their hand from the scope to manipulate the treatment device. Aiming to improve this situation, we developed a new device called the Thumb Drive. Patients and methods: The Thumb Drive comprises a controller and catheter. After attaching the controller to the endoscope’s grip, the catheter is inserted into the forceps channel. The treatment device is then inserted into the Thumb Drive and fixed with its tip protruding from the endoscope tip. A single endoscopist resected 10 lesions in a porcine stomach by endoscopic submucosal dissection (ESD) using the Thumb Drive. Results: All lesions were resected en bloc using this new device without any perforations. The mean incision, dissection, and operative times were 97.2 ± 48.7 seconds, 121.6 ± 53.6 seconds, and 218.8 ± 67.8 seconds, respectively. Conclusions: The Thumb Drive enables the endoscopist to manipulate the treatment device with the thumb while handling the endoscope with the right hand during ESD. Its utility should be examined in in vivo studies as a next step.
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- 2014
4. Clinical advantage of endoscopic submucosal dissection over endoscopic mucosal resection for early mesopharyngeal and hypopharyngeal cancers
- Author
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Daisuke Kikuchi, Toshifumi Mitani, H. Takeda, Toshiro Iizuka, Satoshi Yamashita, Shu Hoteya, Masanori Nakamura, and Naohisa Yahagi
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Male ,medicine.medical_specialty ,Endoscopic mucosal resection ,Metastasis ,Pharyngectomy ,health services administration ,medicine ,Carcinoma ,Humans ,Lymph node ,health care economics and organizations ,Aged ,Retrospective Studies ,Hypopharyngeal Neoplasms ,Mucous Membrane ,business.industry ,Dissection ,Gastroenterology ,En bloc resection ,Endoscopy ,Retrospective cohort study ,Endoscopic submucosal dissection ,Middle Aged ,medicine.disease ,Subcutaneous Emphysema ,Surgery ,Hypopharynx ,surgical procedures, operative ,medicine.anatomical_structure ,Lymphatic Metastasis ,Carcinoma, Squamous Cell ,Female ,Neoplasm Recurrence, Local ,medicine.symptom ,business ,Subcutaneous emphysema - Abstract
Background and study aims: In previous series, endoscopic mucosal resection (EMR) has been used for the treatment of early-stage mesopharyngeal and hypopharyngeal cancers to preserve patients’ quality of life. Endoscopic submucosal dissection (ESD) offers potential advantages in comparison to EMR. So the aim of this retrospective study was to assess the utility of ESD compared with EMR for early-stage cancers of the meso- and hypopharynx. Patients and methods: We studied 56 patients with 69 lesions who underwent either EMR or ESD between April 2001 and December 2008. EMR was performed until January 2007, and ESD was performed from February 2007 onward. We evaluated the en bloc resection rate, R0 resection rate, and treatment-related complications as short-term outcomes. Local recurrence, lymph node metastasis, and disease-related deaths were compared to evaluate long-term outcomes. Results: The en bloc and R0 resection rates were respectively 98 % and 79 % in the ESD group and 37 % and 26 % in the EMR group. There were no cases of treatment-related complications in the EMR group, but postoperative subcutaneous emphysema was observed in two patients in the ESD group. In the EMR group, one patient developed a local recurrence and one developed metastasis to the cervical lymph node and died of primary cancer. Conclusions: ESD is a useful method of treatment for early mesopharyngeal and hypopharyngeal cancers and may be superior to EMR.
- Published
- 2011
5. Endoscopic submucosal dissection for treatment of mesopharyngeal and hypopharyngeal carcinomas
- Author
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H. Takeda, Toshiro Iizuka, Daisuke Kikuchi, Shu Hoteya, and Naohisa Yahagi
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Larynx ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Pharyngeal lesions ,Laryngoscopy ,Gastroenterology ,Retrospective cohort study ,Endoscopic submucosal dissection ,Laryngeal Edema ,Surgery ,Endoscopy ,medicine.anatomical_structure ,Otorhinolaryngology ,Medicine ,business - Abstract
Background and study aims Application of the endoscopic submucosal dissection (ESD) technique, as well as elevation of the larynx in cooperation with an otolaryngologist, under general anesthesia has enabled en-block resection of early mesopharyngeal and hypopharyngeal carcinomas. The aim of this study was to retrospectively evaluate the safety of ESD and the efficacy of the elevation of the larynx for treatment of early mesopharyngeal and hypopharyngeal carcinomas. Patients and methods The study included 16 lesions in 13 patients who underwent ESD. To provide a sufficient working space, the larynx was elevated under direct laryngoscopy, and a tube was inserted and fixed onto the laryngeal side using the slot on the back of the laryngoscope. Results The median maximum diameter of the lesions was 12.5 mm (range 2 - 37 mm). The en-block resection rate was 93.8 %. Lateral surgical margins in two patients were difficult to evaluate for technical reasons. The tube could not be removed from four patients on the day of the procedure due to laryngeal edema caused by the local injection. No serious complications were observed. Oral food intake was possible after a mean of 3.3 postoperative days. Conclusions With adequate intraoperative and postoperative management, ESD with elevation of the larynx may be very efficient and safe for endoscopic treatment of pharyngeal lesions.
- Published
- 2009
6. Polyglycolic acid sheet application to prevent esophageal stricture after endoscopic submucosal dissection for esophageal squamous cell carcinoma
- Author
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Mitsuru Kaise, Shu Hoteya, Daisuke Kikuchi, Akihiro Yamada, Yoshiaki Kajiyama, and Toshiro Iizuka
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Esophageal Neoplasms ,Fibrin Tissue Adhesive ,Gastroenterology ,Internal medicine ,medicine ,Carcinoma ,Humans ,Esophagus ,Fibrin glue ,Adverse effect ,Aged ,Aged, 80 and over ,Mucous Membrane ,business.industry ,Dissection ,Surgical wound ,Endoscopic submucosal dissection ,Middle Aged ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Esophageal stricture ,Carcinoma, Squamous Cell ,Esophageal Stenosis ,Female ,Tissue Adhesives ,Esophagoscopy ,business ,Complication ,Polyglycolic Acid ,Follow-Up Studies - Abstract
Background and study aim: Esophageal stricture following endoscopic submucosal dissection (ESD) can be a serious complication in patients with large mucosal defects. This preliminary study examined the efficacy of using a polyglycolic acid (PGA) sheet with fibrin glue for the prevention of esophageal stricture after ESD. Patients and methods: A total of 15 patients were enrolled. After resection, PGA sheets were placed over the surgical wound. The size of the mucosal defect was estimated by dividing the circumference of the esophagus into 12 parts of equal size. The occurrence of esophageal stricture at 6 weeks, along with the proportion of patients who had PGA sheet remaining in place 1 week and 2 weeks after ESD, and the occurrence of adverse events were investigated. Results: The size of mucosal defects in the 15 patients were 7/12 (n = 4), 8 /12 (n = 5), 9/12 (n = 4), 10/12 (n = 1) and 11/12 (n = 1). Esophageal stricture occurred in 1/13 patients (7.7 %; two patients were not included in the analysis because they had required surgical resection during the follow-up period). The PGA sheet remained at 1 week after ESD in 13/15 patients (86.7 %) and at 2 weeks after ESD in 6/15 patients (40 %). No adverse events were observed. Conclusion: PGA sheets may have the potential to prevent esophageal stricture.
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- 2014
7. Endocytoscopy is a promising modality with high diagnostic accuracy for gastric cancer
- Author
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Mitsuru Kaise, Satoshi Yamashita, Shu Hoteya, Yasutaka Kuribayashi, Akira Matsui, Daisuke Kikuchi, Kosuke Nomura, Osamu Ogawa, Ryusuke Kimura, Akihiro Yamada, Toshiro Iizuka, Tsukasa Furuhata, Yasuo Ohkura, and Toshifumi Mitani
- Subjects
Adenoma ,Pathology ,medicine.medical_specialty ,Pilot Projects ,Adenocarcinoma ,Sensitivity and Specificity ,Stomach Neoplasms ,Biopsy ,Gastroscopy ,medicine ,Gastric mucosa ,Atypia ,Humans ,Prospective Studies ,Coloring Agents ,medicine.diagnostic_test ,business.industry ,Stomach ,Gastroenterology ,Cancer ,medicine.disease ,Early Gastric Cancer ,Methylene Blue ,medicine.anatomical_structure ,Gastric Mucosa ,Feasibility Studies ,Gentian Violet ,business - Abstract
Background and study aim: Endocytoscopy (ECS) enables in vivo microscopic imaging, which allows analysis of mucosal structures at the cellular level; however, limited data are available on the validity of ECS in the stomach. The aim of this study was to evaluate the feasibility of ECS in the diagnosis of early gastric cancer. Patients and methods: Gastric lesions that were the targets of histopathological diagnosis by endoscopic submucosal dissection or biopsy specimen were prospectively enrolled and evaluated using a single charge-coupled device-integrated endocytoscope, following double staining with crystal violet and methylene blue. High grade ECS atypia was defined according to specific irregularities in gland structure and cell nuclei. The primary end point was the accuracy of ECS diagnosis for gastric cancer, using histopathological diagnosis as the gold standard. Results: A total of 82 lesions were investigated, including 23 early gastric cancers, 10 gastric adenomas, and 49 non-neoplastic lesions. Ten lesions could not be clearly observed by ECS because of poor staining due to viscous mucus or plaque; thus, assessability rates with ECS were 88 % in total and 91 % for gastric cancer. High grade ECS atypia was observed in 86 % of assessable gastric cancers, but not in any cases of gastric adenomas or non-neoplastic lesions. The sensitivity, specificity, positive and negative predictive values of high grade ECS atypia as the criterion for the diagnosis of gastric cancer were 86 %, 100 %, 100 %, and 94 %, respectively. No serious complications occurred during or after the examinations. Conclusion: ECS is a clinically feasible modality to obtain in vivo histology, with high diagnostic accuracy in gastric cancer.
- Published
- 2014
8. Polyglycolic acid sheet application to prevent esophageal stricture after endoscopic submucosal dissection for esophageal squamous cell carcinoma.
- Author
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Toshiro Iizuka, Daisuke Kikuchi, Akihiro Yamada, Shu Hoteya, Yoshiaki Kajiyama, and Mitsuru Kaise
- Subjects
GLYCOLIC acid ,ENDOSCOPY ,SQUAMOUS cell carcinoma ,FIBRIN ,ESOPHAGOGASTRIC junction cancer ,CANCER treatment - Abstract
Background and study aim: Esophageal stricture following endoscopic submucosal dissection (ESD) can be a serious complication in patients with large mucosal defects. This preliminary study examined the efficacy of using a polyglycolic acid (PGA) sheet with fibrin glue for the prevention of esophageal stricture after ESD. Patients and methods: A total of 15 patients were enrolled. After resection, PGA sheets were placed over the surgical wound. The size of the mucosal defect was estimated by dividing the circumference of the esophagus into 12 parts of equal size. The occurrence of esophageal stricture at 6 weeks, along with the proportion of patients who had PGA sheet remaining in place 1 week and 2 weeks after ESD, and the occurrence of adverse events were investigated. Results: The size of mucosal defects in the 15 patients were 7/12 (n=4), 8/12 (n=5), 9/12 (n=4), 10/12 (n=1) and 11/12 (n=1). Esophageal stricture occurred in 1/13 patients (7.7 %; two patients were not included in the analysis because they had required surgical resection during the follow- up period). The PGA sheet remained at 1 week after ESD in 13/15 patients (86.7 %) and at 2 weeks after ESD in 6/15 patients (40 %). No adverse events were observed. Conclusion: PGA sheets may have the potential to prevent esophageal stricture. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
9. Endocytoscopy is a promising modality with high diagnostic accuracy for gastric cancer.
- Author
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Mitsuru Kaise, Yasuo Ohkura, Toshiro Iizuka, Ryusuke Kimura, Kosuke Nomura, Yasutaka Kuribayashi, Akihiro Yamada, Satoshi Yamashita, Tsukasa Furuhata, Daisuke Kikuchi, Osamu Ogawa, Akira Matsui, Toshifumi Mitani, and Shu Hoteya
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STOMACH cancer ,CELL nuclei ,HISTOPATHOLOGY ,ADENOMATOUS polyps ,HISTOLOGY - Abstract
Background and study aim: Endocytoscopy (ECS) enables in vivo microscopic imaging, which allows analysis of mucosal structures at the cellular level; however, limited data are available on the validity of ECS in the stomach. The aim of this study was to evaluate the feasibility of ECS in the diagnosis of early gastric cancer. Patients and methods: Gastric lesions that were the targets of histopathological diagnosis by endoscopic submucosal dissection or biopsy specimen were prospectively enrolled and evaluated using a single charge-coupled device-integrated endocytoscope, following double staining with crystal violet and methylene blue. High grade ECS atypia was defined according to specific irregularities in gland structure and cell nuclei. The primary end point was the accuracy of ECS diagnosis for gastric cancer, using histopathological diagnosis as the gold standard. Results: A total of 82 lesionswere investigated, including 23 early gastric cancers, 10 gastric adenomas, and 49 non-neoplastic lesions. Ten lesions could not be clearly observed by ECS because of poor staining due to viscous mucus or plaque; thus, assessability rates with ECS were 88% in total and 91% for gastric cancer. High grade ECS atypiawas observed in 86% of assessable gastric cancers, but not in any cases of gastric adenomas or non-neoplastic lesions. The sensitivity, specificity, positive and negative predictive values of high grade ECS atypia as the criterion for the diagnosis of gastric cancer were 86%, 100%, 100%, and 94%, respectively. No serious complications occurred during or after the examinations. Conclusion: ECS is a clinically feasible modality to obtain in vivo histology, with high diagnostic accuracy in gastric cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
10. A new device for simultaneous manipulation of an endoscope and a treatment device during procedures: an ex vivo animal study.
- Author
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Daisuke Kikuchi, Akihiro Yamada, Toshiro Iizuka, Kosuke Nomura, Yasutaka Kuribayashi, Ryusuke Kimura, Satoshi Yamashita, Tsukasa Furuhata, Akira Matsui, Toshifumi Mitani, Osamu Ogawa, Shu Hoteya, Naohisa Yahagi, and Mitsuru Kaise
- Subjects
ENDOSCOPY ,DIAGNOSIS ,CATHETERS ,DRUG delivery devices ,DIALYSIS catheters - Abstract
Background and study aims: Endoscopists must maneuver both endoscope and treatment device during procedures, requiring them to release their hand from the scope to manipulate the treatment device. Aiming to improve this situation, we developed a new device called the Thumb Drive. Patients and methods: The Thumb Drive comprises a controller and catheter. After attaching the controller to the endoscope's grip, the catheter is inserted into the forceps channel. The treatment device is then inserted into the Thumb Drive and fixed with its tip protruding from the endoscope tip. A single endoscopist resected 10 lesions in a porcine stomach by endoscopic submucosal dissection (ESD) using the Thumb Drive. Results: All lesions were resected en bloc using this new device without any perforations. The mean incision, dissection, and operative times were 97.2±48.7 seconds, 121.6±53.6 seconds, and 218.8±67.8 seconds, respectively. Conclusions: The Thumb Drive enables the endoscopist to manipulate the treatment device with the thumb while handling the endoscope with the right hand during ESD. Its utility should be examined in in vivo studies as a next step. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
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