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IN 1930 Cushing (I) described a peculiar syndrome associated with basophilic tU-mors of the pituitary. This syndrome is characterized by obesity confined to the face and trunk, redness of the face, cyanotic striae distensae over the trunk, ec-chymoses on the lower extremities, and acneiform eruptions. In females there is also amenorrhea, drying and thinning of the hair on the head with the development of hirsutism of the face and trunk. In the male sexual powers may be impaired. In addi-tion the blood pressure becomes elevated and eventually arterial changes of the malig-nant nephrosclerotic type are found. In a large proportion, but not all, carbohydrate tolerance is impaired. Osteoporosis, especially affecting the spine, is common. Since the appearance of Cushing's monograph the cases reported with this syn-drome have multiplied with great rapidity. However, in a large proportion, instead of basophilic tumors, hypertrophy or tumors of the adrenal cortex have been found.