Search

Your search keyword '"Body Weight/drug effects"' showing total 2 results
Start Over Descriptor "Body Weight/drug effects" Journal endocrinology
2 results on '"Body Weight/drug effects"'

1. Chronic Neuropeptide Y Infusion into the Lateral Ventricle Induces Sustained Feeding and Obesity in Mice Lacking Either Npy1r or Npy5r Expression

Author

Thierry Pedrazzini, Paula D. Raposinho, Michel L. Aubert, Richard D. Palmiter, and Richard B. White

Subjects
Leptin, Male, Pro-Opiomelanocortin, Eating/drug effects, Adipose Tissue/anatomy & histology, Obesity/physiopathology, Eating, Mice, chemistry.chemical_compound, Corticosterone/blood, Endocrinology, Corticosterone, Lateral Ventricles, Insulin, Medicine, Neuropeptide Y, Neurotransmitter, Receptor, Mice, Knockout, ddc:618, biology, RNA, Messenger/analysis, Neuropeptide Y receptor, humanities, Adipose Tissue, Hypothalamus, Pro-Opiomelanocortin/genetics, medicine.drug, medicine.medical_specialty, Drinking, Hyperphagia/chemically induced, Hyperphagia, Neuropeptide Y/genetics/pharmacology, Proopiomelanocortin, Orexigenic, Internal medicine, mental disorders, Animals, Feeding Behavior/drug effects, Body Weight/drug effects, Obesity, RNA, Messenger, Injections, Intraventricular, Receptors, Neuropeptide Y/genetics, business.industry, Drinking/drug effects, Body Weight, Feeding Behavior, Receptors, Neuropeptide Y, Mice, Inbred C57BL, chemistry, Leptin/blood, biology.protein, Insulin/blood, business
Abstract

Neuropeptide Y (NPY) is a powerful orexigenic neurotransmitter. The NPY Y1 and Y5 receptors have been implicated in mediating the appetite-stimulating activity of NPY. To further investigate the importance of these two receptors in NPY-induced hyperphagia after chronic central administration, we used mice lacking either Npy1r or Npy5r expression. NPY infusion into the lateral ventricle of wild-type mice stimulated food intake and induced obesity over a 7-d period. Fat pad weight as well as plasma insulin, leptin, and corticosterone levels were strongly increased in NPY-treated mice. In addition, NPY infusion resulted in a significant decrease in hypothalamic NPY and proopiomelanocortin expression. Interestingly, the lack of either Npy1r or Npy5r expression in knockout mice did not affect such feeding response to chronic NPY infusion. Moreover, the obesity syndrome that developed in these animals was similar to that in wild-type animals. Taken together, these data strongly suggest biological redundancies between Y1 and Y5 receptor signaling in the NPY-mediated control of food intake.

Published
2004
Full Text
View/download PDF

2. Different effects of continuous infusion of interleukin-1 and interleukin-6 on the hypothalamic-hypophysial-thyroid axis

Author

Haasteren, G.A.C. (Goedele) van, Meer, M.J. van der, Hermus, A.R.M.M. (Ad), Linkels, E., Klootwijk, W. (Willem), Kaptein, E. (Ellen), Toor, H. (Hans) van, Sweep, C.G., Visser, T.J. (Theo), Greef, W.J. de, Haasteren, G.A.C. (Goedele) van, Meer, M.J. van der, Hermus, A.R.M.M. (Ad), Linkels, E., Klootwijk, W. (Willem), Kaptein, E. (Ellen), Toor, H. (Hans) van, Sweep, C.G., Visser, T.J. (Theo), and Greef, W.J. de

Abstract

The cytokines interleukin-1 (IL-1) and IL-6 are thought to be important mediators in the suppression of thyroid function during nonthyroidal illness. In this study we compared the effects of IL-1 and IL-6 infusion on the hypothalamus-pituitary-thyroid axis in rats. Cytokines were administered by continuous ip infusion of 4 micrograms IL-1 alpha/day for 1, 2, or 7 days or of 15 micrograms IL-6/day for 7 days. Body weight and temperature, food and water intake, and plasma TSH, T4, free T4 (FT4), T3, and corticosterone levels were measured daily, and hypothalamic pro-TRH messenger RNA (mRNA) and hypophysial TSH beta mRNA were determined after termination of the experiments. Compared with saline-treated controls, infusion of IL-1, but not of IL-6, produced a transient decrease in food and water intake, a transient increase in body temperature, and a prolonged decrease in body weight. Both cytokines caused transient decreases in plasma TSH and T4, which were greater and more prolonged with IL-1 than with IL-6, whereas they effected similar transient increases in the plasma FT4 fraction. Infusion with IL-1, but not IL-6, also induced transient decreases in plasma FT4 and T3 and a transient increase in plasma corticosterone. Hypothalamic pro-TRH mRNA was significantly decreased (-73%) after 7 days, but not after 1 or 2 days, of IL-1 infusion and was unaffected by IL-6 infusion. Hypophysial TSH beta mRNA was significantly decreased after 2 (-62%) and 7 (-62%) days, but not after 1 day, of IL-1 infusion and was unaffected by IL-6 infusion. These results are in agreement with previous findings that IL-1, more so than IL-6, directly inhibits thyroid hormone production. They also indicate that IL-1 and IL-6 both decrease plasma T4 binding. Furthermore, both cytokines induce an acute and dramatic decrease in plasma TSH before (IL-1) or even without (IL-6) a decrease in hypothalamic pro-TRH mRNA or hypophysial TSH beta mRNA, suggesting that the acute decrease in TSH secretion is

Published
1994

Catalog

Books, media, physical & digital resources
See catalog results