1. Sporadic type composite pheochromocytoma with neuroblastoma: clinicomorphologic, DNA content and ret gene analysis
- Author
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Arturo Cérbulo-Vázquez, Isabel Alvarado-Cabrero, Leticia Bornstein-Quevedo, Ricardo López-Romero, Armando Gamboa-Domínguez, Fernando Candanedo-Gonzalez, and Mauricio Salcedo-Vargas
- Subjects
endocrine system ,Pathology ,medicine.medical_specialty ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,DNA Mutational Analysis ,Adrenal Gland Neoplasms ,Pheochromocytoma ,Biology ,RET proto-oncogene ,medicine.disease_cause ,Polymerase Chain Reaction ,Pathology and Forensic Medicine ,Exon ,Neuroblastoma ,Endocrinology ,Proto-Oncogene Proteins ,medicine ,Biomarkers, Tumor ,Drosophila Proteins ,Humans ,neoplasms ,Aged ,DNA Primers ,Mutation ,Proto-Oncogene Proteins c-ret ,Receptor Protein-Tyrosine Kinases ,Neoplasms, Second Primary ,General Medicine ,DNA, Neoplasm ,Middle Aged ,medicine.disease ,Flow Cytometry ,Diploidy ,Immunohistochemistry ,Female - Abstract
Composite pheochromocytomas (CP) account for only 3% of all pheochromocytomas. We analyzed the clinical, immunohistochemical, ultrastructural, DNA content, and 634 ret mutation features in a 56-year-old Mexican woman with CP localized in the right adrenal gland and associated to a blood pressure of 140/90 mmHg. Clinical symptoms were absent after surgery. The tumor showed pheochromocytoma and neuroblastoma components. This dual phenotype was supported by light microscopy and corroborated by immunohistochemistry and ultrastructural findings. Flow cytometric analysis showed that both components were diploid. A genetic mutational analysis of the ret oncogene in exon 11 showed no 634 mutation. This case demonstrates the indolent behavior of neuroblastoma associated to a sporadic-type CP in an adult patient.
- Published
- 2001