Search

Your search keyword '"Yalcin, Basaran"' showing total 2 results
Start Over Author "Yalcin, Basaran" Journal endocrine journal
2 results on '"Yalcin, Basaran"'

1. Endothelial dysfunction, insulin resistance and inflammation in congenital hypogonadism, and the effect of testosterone replacement

Author

Omer Azal, Mahmut Ilker Yilmaz, Serkan Tapan, Abdullah Taslipinar, Erol Bolu, Aydogan Aydogdu, Mustafa Dinc, Alper Sonmez, Kamil Baskoy, Yalcin Basaran, Cem Haymana, Cem Barçın, Mahmut Yazici, and Coskun Meric

Subjects
Adult, Blood Glucose, Male, medicine.medical_specialty, Hormone Replacement Therapy, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Population, Body Mass Index, Young Adult, chemistry.chemical_compound, Endocrinology, Insulin resistance, Risk Factors, Internal medicine, medicine, Humans, Insulin, Testosterone, Endothelial dysfunction, education, Triglycerides, Inflammation, education.field_of_study, biology, business.industry, Hypogonadism, C-reactive protein, medicine.disease, Treatment Outcome, chemistry, biology.protein, Homeostatic model assessment, Endothelium, Vascular, Insulin Resistance, Waist Circumference, business, Asymmetric dimethylarginine, Hypogonadotrophic hypogonadism
Abstract

Patients with hypogonadism have poor cardiovascular and metabolic outcomes, and the effect of testosterone replacement therapy (TRT) is not clear. We investigated the presence of inflammation, insulin resistance and endothelial dysfunction in an unconfounded population of congenital hypogonadotrophic hypogonadism (CHH) and the effect of TRT on these subjects. A total of 60 patients with CHH (mean age 21.82±2.22 years) and 70 healthy control subjects (mean age 21.32±1.13 years) were enrolled. The demographic parameters, Asymmetric dimethylarginine (ADMA), TNF-like weak inducer of apoptosis (TWEAK), high sensitive C reactive protein (hs-CRP) and homeostatic model assessment of insulin resistance (HOMA-IR) levels were measured before and after TRT. The patients had higher Waist Circumferences (WC) (p=0.009), Diastolic Blood Pressures (p=0.02), Triglycerides (p=0.03), ADMA, insulin and HOMA-IR levels (p

Published
2015

2. Increased frequency of anxiety, depression, quality of life and sexual life in young hypogonadotropic hypogonadal males and impacts of testosterone replacement therapy on these conditions

Author

Erol Bolu, Halil Akbulut, Servet Yuksel, Özcan Uzun, Alper Sonmez, Yalcin Basaran, Umit Aydogan, Kenan Saglam, and Aydogan Aydogdu

Subjects
Adult, Male, medicine.medical_specialty, Hormone Replacement Therapy, Sexual Behavior, Endocrinology, Diabetes and Metabolism, Beck Anxiety Inventory, Anxiety, Young Adult, Endocrinology, Hypogonadotropic hypogonadism, Internal medicine, Prevalence, medicine, Humans, Testosterone, Life Style, Depression, business.industry, Hypogonadism, Beck Depression Inventory, Testosterone (patch), medicine.disease, Sexual dysfunction, Research Design, Case-Control Studies, Quality of Life, Congenital Hypogonadotropic Hypogonadism, medicine.symptom, Sexual function, business
Abstract

Hypogonadotropic hypogonadism is defined as the failure in production of gonadal hormones, thus resulting in lower amounts of testosterone. Depression, anxiety and decreased quality of life are the most common psychopathological conditions in young hypogonadal men. The aim of the present study was to assess the still debated relationship with testosterone levels and psychological symptoms in young male patients with congenital hypogonadotropic hypogonadism (CHH). Thirty-nine young male patients with CHH and 40 age-matched healthy males were enrolled in the present study. The impact of testosterone replacement treatment (TRT) on the patients' anxiety and depression levels, sexual function and quality of life were assessed before and after 6 months of treatment using valid and reliable scales, including the Short Form-36 (SF-36), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Arizona Sexual Experiences (ASEX). Patients with CHH had significantly higher scores for BDI, BAI, and ASEX than the control subjects at baseline (p=0.011, p=0.036, p

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results