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Start Over Author "Alice Fletcher" Journal endocrine abstracts
22 results on '"Alice Fletcher"'

5. Drug repurposing identifies inhibitors of the proteostasis network to augment radioiodine uptake in combinatorial approaches targeting thyroid cancer

Author

Martin L. Read, Caitlin Thornton, Hannah Nieto, Liam R. Cox, Vicki Smith, Rashida Khan, Holly V. Adcock, Luke J. Alderwick, Christopher McCabe, Katie Brookes, Alice Fletcher, Mohammed Alshahrani, Jamie R.M. Webster, and Kristien Boelaert

Subjects
medicine.diagnostic_test, business.industry, Glucose uptake, Skeletal muscle, Type 2 diabetes, medicine.disease, Drug repositioning, Proteostasis, Metabolomics, medicine.anatomical_structure, Positron emission tomography, medicine, Cancer research, business, Thyroid cancer
Published
2020

6. The proto-oncogene PBF mediates Src modulation of radioiodine uptake

Author

Alice Fletcher, Martin L. Read, C McCabe, Rebecca Thompson, Hannah Nieto, Kate Brookes, Vicki Smith, Caitlin Thornton, Saroop Raja, Kristien Boelaert, and Mohammed Alshahrani

Subjects
Oncogene, Radioiodine uptake, Chemistry, Cancer research, Proto-oncogene tyrosine-protein kinase Src
Published
2019

7. Driver events in thyroid cancer recurrence

Author

Katie Brookes, Kristien Boelaert, Alice Fletcher, Martin L. Read, Albert Nobre de Menezes, Jean-Baptiste Cazier, C McCabe, Vicki Smith, Hannah Nieto, Hisham Mehanna, Caitlin Thornton, and Mohammed Alshahrani

Subjects
Oncology, medicine.medical_specialty, business.industry, Internal medicine, medicine, business, medicine.disease, Thyroid cancer
Published
2019

8. A high-throughput yellow fluorescent protein (YFP) cell-based screen identifies autophagy modulators to increase the effectiveness of radioiodine therapy

Author

Vicki Smith, Mohammed Alshahrani, Martin L. Read, Christopher McCabe, Jamie R.M. Webster, Kristien Boelaert, Luke J. Alderwick, Caitlin Thornton, Alan S. Verkman, Hannah Nieto, Rashida Khan, Katie Baker, Alice Fletcher, and Peter M. Haggie

Subjects
Yellow fluorescent protein, biology, Chemistry, Autophagy, biology.protein, Radioiodine therapy, Throughput (business), Cell biology, Cell based
Published
2019

10. Novel driver mutations in thyroid cancer recurrence

Author

Martin L. Read, Kate Baker, Hisham Mehanna, Caitlin Thornton, Vicki Smith, Cazier Jean Baptiste, Mohammed Alshahrani, Christopher McCabe, Kristien Boelaert, Hannah Nieto, Menezes Albert Nobre de, and Alice Fletcher

Subjects
Oncology, medicine.medical_specialty, business.industry, Internal medicine, medicine, business, medicine.disease, Thyroid cancer
Published
2019

11. Biochemical analysis of radioiodine uptake enhancement in endocrine cancer

Author

Martin L. Read, Christopher McCabe, Katie Brookes, Mohammed Alshahrani, Caitlin Thornton, Rebecca Thompson, Alice Fletcher, Kristien Boelaert, Vicki Smith, and Hannah Nieto

Subjects
Radioiodine uptake, business.industry, Cancer research, Medicine, business, Endocrine cancer
Published
2018

12. Oncogenic action of pituitary-tumor transforming gene (PBF) in head and neck cancer is associated with poorer overall survival

Author

Rebecca Thompson, Martin L. Read, Alice Fletcher, Moray J. Campbell, Hannah Nieto, Katie Baker, Bhavika Modasia, Hisham Mehanna, Andrew S. Turnell, Kristien Boelaert, Christopher McCabe, and Vicki Smith

Subjects
Action (philosophy), Pituitary Tumor Transforming Gene, business.industry, Head and neck cancer, Cancer research, medicine, Overall survival, medicine.disease, business
Published
2018

13. Identification of novel sodium iodide symporter (NIS) interactors which modulate radioiodine uptake

Author

Vikki Poole, Caitlin Thornton, Martin L. Read, Kristien Boelaert, Vicki Smith, Christopher McCabe, Rebecca Thompson, Mohammed Alshahrani, Kate Baker, Alice Fletcher, Andy Turnell, and Hannah Nieto

Subjects
Sodium-iodide symporter, Chemistry, Radioiodine uptake, Golgi apparatus, medicine.disease, Interactome, Cell biology, Papillary thyroid cancer, symbols.namesake, medicine, symbols, Thyroid cancer, health care economics and organizations, Platelet factor 4, Function (biology)
Abstract

Patients termed to have radioiodine-refractory differentiated thyroid cancer (RR-DTC) cannot accumulate sufficient radioiodine for a therapeutic response due to sodium iodide symporter (NIS) dysregulation via diminished expression and/or altered plasma membrane localisation. Previous studies identified novel therapeutics to increase NIS expression, but these are associated with poor tolerance and resistance. Meanwhile, regulation of NIS plasma membrane localisation remains poorly defined and, despite protein-protein interactions being well-described to modulate trafficking events, the NIS interactome is limited. Here, two novel functional NIS interactors – ADP-ribosylation factor 4 (ARF4) and valosin-containing protein (VCP) – were identified by mass spectrometry, which positively and negatively modulated radioiodine uptake respectively. In papillary thyroid cancer (PTC), ARF4 is downregulated, and VCP overexpressed, which may provide a putative explanation for repressed NIS function. Subsequent investigations identified co-localisation between ARF4 and NIS at the Golgi as well as co-incident trafficking at the plasma membrane, which led to the hypothesis that ARF4 promotes NIS trafficking to the plasma membrane. In contrast, VCP decreased NIS protein expression, which was suggestive of a role for VCP in NIS processing and degradation. Pharmacological inhibitors Eeyarestatin-1 and NMS-873 overcame VCP inhibition of NIS function, which may highlight a novel therapeutic strategy for RR-DTC.

Published
2018

17. High tumoral expression of PBF and PTTG modulates the DNA damage response and is associated with poor survival in thyroid cancer

Author

Martin L. Read, Bhavika Modasia, Andrea Bacon, Neil Sharma, Waraporn Imruetaicharoenchoke, Vicki Smith, Jim Fong, Christopher McCabe, Alice Fletcher, John Watkinson, Kristien Boelaert, Andrew S. Turnell, Hannah Nieto, and Rebecca Thompson

Subjects
Pathology, medicine.medical_specialty, business.industry, DNA damage, medicine, medicine.disease, business, Thyroid cancer
Published
2016

19. Pharmacological enhancement of radioiodine uptake through Src kinase inhibition

Author

Alice Fletcher, Martin L. Read, Kristien Boelaert, Neil Sharma, Waraporn Imruetaicharoenchoke, Bhavika Modasia, Hannah Nieto, Rebecca Thompson, Vikki Poole, Christopher McCabe, and Vicki Smith

Subjects
Radioiodine uptake, Chemistry, Cancer research, Proto-oncogene tyrosine-protein kinase Src
Published
2016

21. Pituitary tumor transforming gene binding factor (PBF): a novel modulator of iodide uptake and target for Src phosphorylation in breast cancer

Author

Vicki Smith, Martin L. Read, Neil Sharma, Vikki Poole, Kristien Boelaert, Rebecca Thompson, Christopher McCabe, Alice Fletcher, Bhavika Modasia, and Waraporn Imruetaicharoenchoke

Subjects
chemistry.chemical_classification, medicine.medical_specialty, Breast cancer, Endocrinology, Chemistry, Pituitary Tumor Transforming Gene, Internal medicine, Iodide, medicine, Cancer research, Phosphorylation, medicine.disease, Proto-oncogene tyrosine-protein kinase Src
Published
2015

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