1. Serum aminotransferase levels and angiographic coronary artery disease in octogenarians
- Author
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Dinesh Singal, Shivank Madan, Snehal R. Patel, and C. S. Pitchumoni
- Subjects
Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Coronary Artery Disease ,Coronary Angiography ,digestive system ,Gastroenterology ,Coronary artery disease ,fluids and secretions ,Endocrinology ,Insulin resistance ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,Aspartate Aminotransferases ,Endothelial dysfunction ,Coronary atherosclerosis ,Aged, 80 and over ,biology ,business.industry ,Alanine Transaminase ,medicine.disease ,Troponin ,digestive system diseases ,biology.protein ,Biomarker (medicine) ,Female ,Metabolic syndrome ,business ,Biomarkers - Abstract
Elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels have been associated with metabolic syndrome (MS), insulin resistance (IR), diabetes, endothelial dysfunction, coronary atherosclerosis, and cardiovascular (CVS) events, in addition to diseases of the liver [ 1– 4]. Studies have also shown that elevated AST/ ALT ratio in women could predict severity of coronary atherosclerosis [ 3]. Hence, in recent years, there has been a renewed interest in using ALT and AST as biomarkers for assessment of CVS risk. Serum AST levels were first described as a biomarker for myocardial necrosis in the 1950s [ 5] but were replaced by other more sensitive and specific biomarkers like creatinine kinase myocardial b fraction (CKMB) and troponins.
- Published
- 2015