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The ancestral groups of the Colombia, historically have experienced and resisted activities of resource extractivism, today suffer a more sophisticated level of this long and uninterrupted process: cultural extractivism. The research results that are visible in this reflection article address a global characterization with local impact of the trend called biopiracy. For this reason, it is intended to analyze with the methodologies of legal hermeneutics, the category of bioprospecting of unconventional knowledge of ancestral groups; the global panorama and the new socio-legal realities that this mega trend is provoking are also pointed out. [ABSTRACT FROM AUTHOR]