1. Influenza (H5N1) viruses in poultry, Russian Federation, 2005-2006.
- Author
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Lipatov AS, Evseenko VA, Yen HL, Zaykovskaya AV, Durimanov AG, Zolotykh SI, Netesov SV, Drozdov IG, Onishchenko GG, Webster RG, and Shestopalov AM
- Subjects
- Animals, Animals, Wild virology, Birds virology, Chickens, Ferrets, Geese, Influenza A Virus, H5N1 Subtype genetics, Influenza A Virus, H5N1 Subtype pathogenicity, Influenza in Birds virology, Male, Mice, Phylogeny, Poultry Diseases virology, Russia epidemiology, Turkeys, Influenza A Virus, H5N1 Subtype classification, Influenza A Virus, H5N1 Subtype isolation & purification, Influenza in Birds epidemiology, Poultry Diseases epidemiology
- Abstract
We studied 7 influenza (H5N1) viruses isolated from poultry in western Siberia and the European part of the Russian Federation during July 2005-February 2006. Full genome sequences showed high homology to Qinghai-like influenza (H5N1) viruses. Phylogenetic analysis not only showed a close genetic relationship between the H5N1 strains isolated from poultry and wild migratory waterfowls but also suggested genetic reassortment among the analyzed isolates. Analysis of deduced amino acid sequences of the M2 and neuraminidase proteins showed that all isolates are potentially sensitive to currently available antiviral drugs. Pathogenicity testing showed that all studied viruses were highly pathogenic in chickens; for 3 isolates tested in mice and 2 tested in ferrets, pathogenicity was heterogeneous. Pathogenicity in mammalian models was generally correlated with Lys at residue 627 of polymerase basic protein 2.
- Published
- 2007
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